Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100497432> ?p ?o ?g. }
- W3100497432 abstract "Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the leading cause of death from an infectious bacterium and is responsible for 1.8 million deaths annually. The emergence of drug resistance, together with the need for a shorter more effective regimen, has prompted the drive to identify novel therapeutics with the bacterial cell surface emerging as a tractable area for drug development. Mtb assembles a unique, waxy and complex cell envelope comprised of the mycolyl-arabinogalactan-peptidoglycan complex and an outer capsule like layer, which are collectively essential for growth and pathogenicity while serving as an inherent barrier against antibiotics. A detailed understanding of the biosynthetic pathways required to assemble the polymers that comprise the cell surface will enable the identification of novel drug targets as these structures are not present in humans and provide a diversity of biochemical reactions that can be targeted. Herein, we provide an overview of recently described mycobacterial cell wall targeting compounds, novel drug combinations and their modes of action. We anticipate that this summary will enable prioritization of the best pathways to target and triage of the most promising molecules to progress for clinical assessment." @default.
- W3100497432 created "2020-11-23" @default.
- W3100497432 creator A5019918078 @default.
- W3100497432 creator A5063544824 @default.
- W3100497432 creator A5080190398 @default.
- W3100497432 date "2020-11-12" @default.
- W3100497432 modified "2023-10-16" @default.
- W3100497432 title "Cell Surface Biosynthesis and Remodeling Pathways in Mycobacteria Reveal New Drug Targets" @default.
- W3100497432 cites W1513723427 @default.
- W3100497432 cites W1839177883 @default.
- W3100497432 cites W1858605723 @default.
- W3100497432 cites W1964074049 @default.
- W3100497432 cites W1969335793 @default.
- W3100497432 cites W1986130458 @default.
- W3100497432 cites W1993846180 @default.
- W3100497432 cites W1995742852 @default.
- W3100497432 cites W1996907187 @default.
- W3100497432 cites W2002666515 @default.
- W3100497432 cites W2020767338 @default.
- W3100497432 cites W2027067463 @default.
- W3100497432 cites W2032819924 @default.
- W3100497432 cites W2036369371 @default.
- W3100497432 cites W2038469571 @default.
- W3100497432 cites W2045776845 @default.
- W3100497432 cites W2049085776 @default.
- W3100497432 cites W2056523203 @default.
- W3100497432 cites W2057195964 @default.
- W3100497432 cites W2071573946 @default.
- W3100497432 cites W2071973715 @default.
- W3100497432 cites W2076078707 @default.
- W3100497432 cites W2076802796 @default.
- W3100497432 cites W2079996771 @default.
- W3100497432 cites W2096880413 @default.
- W3100497432 cites W2104868544 @default.
- W3100497432 cites W2117610468 @default.
- W3100497432 cites W2119738836 @default.
- W3100497432 cites W2128482141 @default.
- W3100497432 cites W2128491529 @default.
- W3100497432 cites W2130710889 @default.
- W3100497432 cites W2130857599 @default.
- W3100497432 cites W2138397902 @default.
- W3100497432 cites W2142769589 @default.
- W3100497432 cites W2156531683 @default.
- W3100497432 cites W2162550846 @default.
- W3100497432 cites W2162622999 @default.
- W3100497432 cites W2173642732 @default.
- W3100497432 cites W2179039621 @default.
- W3100497432 cites W2219796202 @default.
- W3100497432 cites W2336704559 @default.
- W3100497432 cites W2345528650 @default.
- W3100497432 cites W2346951833 @default.
- W3100497432 cites W2416104868 @default.
- W3100497432 cites W2439307343 @default.
- W3100497432 cites W2476533984 @default.
- W3100497432 cites W2515354748 @default.
- W3100497432 cites W2517433846 @default.
- W3100497432 cites W2518224721 @default.
- W3100497432 cites W2525498392 @default.
- W3100497432 cites W2536434479 @default.
- W3100497432 cites W2566922203 @default.
- W3100497432 cites W2585798883 @default.
- W3100497432 cites W2617852583 @default.
- W3100497432 cites W2740168435 @default.
- W3100497432 cites W2742076607 @default.
- W3100497432 cites W2749383241 @default.
- W3100497432 cites W2752438189 @default.
- W3100497432 cites W2760393221 @default.
- W3100497432 cites W2766287636 @default.
- W3100497432 cites W2782476479 @default.
- W3100497432 cites W2783639437 @default.
- W3100497432 cites W2789232208 @default.
- W3100497432 cites W2790047349 @default.
- W3100497432 cites W2803667595 @default.
- W3100497432 cites W2805456002 @default.
- W3100497432 cites W2810185682 @default.
- W3100497432 cites W2891069378 @default.
- W3100497432 cites W2897723297 @default.
- W3100497432 cites W2915001677 @default.
- W3100497432 cites W2921203336 @default.
- W3100497432 cites W2922262361 @default.
- W3100497432 cites W2925800094 @default.
- W3100497432 cites W2940770254 @default.
- W3100497432 cites W2953060179 @default.
- W3100497432 cites W2953309325 @default.
- W3100497432 cites W2958663082 @default.
- W3100497432 cites W2972225144 @default.
- W3100497432 cites W2974572532 @default.
- W3100497432 cites W2974959442 @default.
- W3100497432 cites W2986825963 @default.
- W3100497432 cites W2988643768 @default.
- W3100497432 cites W2998478784 @default.
- W3100497432 cites W2998864914 @default.
- W3100497432 cites W2999869128 @default.
- W3100497432 cites W3001266181 @default.
- W3100497432 cites W3009599329 @default.
- W3100497432 cites W3011654516 @default.
- W3100497432 cites W3012404094 @default.
- W3100497432 cites W3012522968 @default.
- W3100497432 cites W3014030541 @default.
- W3100497432 cites W3020603994 @default.