FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100503434> ?p ?o ?g. }

• W3100503434 endingPage "292" @default.
• W3100503434 startingPage "287" @default.
• W3100503434 abstract "Researchers must often rely on creatinine measurements to assess kidney function because direct glomerular filtration rates (GFR) and cystatin-c are rarely measured in routine clinical settings. However, HIV treatments often include dolutegravir, raltegravir, rilpivirine or cobicistat, which inhibit the proximal tubular secretion of creatinine without impairing kidney function, thus leading to measurement bias when using creatinine-based estimated GFR (eGFR). We developed eGFR correction factors to account for this potential bias.11,359 treatment-naive HIV-positive individuals in OPERA were included if they initiated dolutegravir, elvitegravir/cobicistat, darunavir/cobicistat, raltegravir, rilpivirine or efavirenz (control) with an eGFR >60 ml/min/1.73 m2. The eGFR was corrected by adding the median decrease reported in the literature to the calculated eGFR; correction factors were not validated. Incidence rates of eGFR <60 ml/min/1.73 m2 (Poisson regression) and the relationship between regimens and eGFR <60 ml/min/1.73 m2 (multivariate Cox proportional hazards models) were estimated with and without eGFR correction.Without eGFR correction, dolutegravir, elvitegravir/cobicistat, darunavir/cobicistat, raltegravir and rilpivirine based regimens were statistically significantly associated with a higher likelihood of eGFR <60 ml/min/1.73 m2 than efavirenz. With eGFR correction, each of these regimens was associated with a statistically significantly lower likelihood of eGFR <60 ml/min/1.73 m2 compared with efavirenz.With increasing use of agents that inhibit tubular creatinine secretion, artificially low eGFR values could lead to erroneous conclusions in studies of HIV treatment and kidney outcomes measured with creatinine-based eGFR equations. Sensitivity analyses assessing the potential magnitude of bias arising from creatinine secretion inhibition should be performed." @default.
• W3100503434 created "2020-11-23" @default.
• W3100503434 creator A5009518467 @default.
• W3100503434 creator A5013318234 @default.
• W3100503434 creator A5015648859 @default.
• W3100503434 creator A5042834426 @default.
• W3100503434 creator A5072292498 @default.
• W3100503434 creator A5087319059 @default.
• W3100503434 date "2019-07-01" @default.
• W3100503434 modified "2023-09-23" @default.
• W3100503434 title "Assessing Bias Introduced in Estimated Glomerular Filtration Rate by the Inhibition of Creatinine Tubular Secretion from Common Antiretrovirals" @default.
• W3100503434 cites W1549276187 @default.
• W3100503434 cites W1970735835 @default.
• W3100503434 cites W2017404902 @default.
• W3100503434 cites W2034122697 @default.
• W3100503434 cites W2061817517 @default.
• W3100503434 cites W2090746606 @default.
• W3100503434 cites W2094811879 @default.
• W3100503434 cites W2099826019 @default.
• W3100503434 cites W2106473738 @default.
• W3100503434 cites W2117577964 @default.
• W3100503434 cites W2122026430 @default.
• W3100503434 cites W2139430929 @default.
• W3100503434 cites W2142538462 @default.
• W3100503434 cites W2145467751 @default.
• W3100503434 cites W2151050670 @default.
• W3100503434 cites W2263291696 @default.
• W3100503434 cites W2322864883 @default.
• W3100503434 cites W2617989063 @default.
• W3100503434 cites W2963036706 @default.
• W3100503434 doi "https://doi.org/10.3851/imp3373" @default.
• W3100503434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33211670" @default.
• W3100503434 hasPublicationYear "2019" @default.
• W3100503434 type Work @default.
• W3100503434 sameAs 3100503434 @default.
• W3100503434 citedByCount "4" @default.
• W3100503434 countsByYear W31005034342019 @default.
• W3100503434 countsByYear W31005034342020 @default.
• W3100503434 countsByYear W31005034342021 @default.
• W3100503434 countsByYear W31005034342022 @default.
• W3100503434 crossrefType "journal-article" @default.
• W3100503434 hasAuthorship W3100503434A5009518467 @default.
• W3100503434 hasAuthorship W3100503434A5013318234 @default.
• W3100503434 hasAuthorship W3100503434A5015648859 @default.
• W3100503434 hasAuthorship W3100503434A5042834426 @default.
• W3100503434 hasAuthorship W3100503434A5072292498 @default.
• W3100503434 hasAuthorship W3100503434A5087319059 @default.
• W3100503434 hasConcept C126322002 @default.
• W3100503434 hasConcept C126894567 @default.
• W3100503434 hasConcept C142462285 @default.
• W3100503434 hasConcept C143998085 @default.
• W3100503434 hasConcept C159047783 @default.
• W3100503434 hasConcept C159641895 @default.
• W3100503434 hasConcept C2777068322 @default.
• W3100503434 hasConcept C2778723075 @default.
• W3100503434 hasConcept C2779182219 @default.
• W3100503434 hasConcept C2779502633 @default.
• W3100503434 hasConcept C2780306776 @default.
• W3100503434 hasConcept C2780404665 @default.
• W3100503434 hasConcept C2780524789 @default.
• W3100503434 hasConcept C2781432083 @default.
• W3100503434 hasConcept C2993143319 @default.
• W3100503434 hasConcept C3013748606 @default.
• W3100503434 hasConcept C71924100 @default.
• W3100503434 hasConceptScore W3100503434C126322002 @default.
• W3100503434 hasConceptScore W3100503434C126894567 @default.
• W3100503434 hasConceptScore W3100503434C142462285 @default.
• W3100503434 hasConceptScore W3100503434C143998085 @default.
• W3100503434 hasConceptScore W3100503434C159047783 @default.
• W3100503434 hasConceptScore W3100503434C159641895 @default.
• W3100503434 hasConceptScore W3100503434C2777068322 @default.
• W3100503434 hasConceptScore W3100503434C2778723075 @default.
• W3100503434 hasConceptScore W3100503434C2779182219 @default.
• W3100503434 hasConceptScore W3100503434C2779502633 @default.
• W3100503434 hasConceptScore W3100503434C2780306776 @default.
• W3100503434 hasConceptScore W3100503434C2780404665 @default.
• W3100503434 hasConceptScore W3100503434C2780524789 @default.
• W3100503434 hasConceptScore W3100503434C2781432083 @default.
• W3100503434 hasConceptScore W3100503434C2993143319 @default.
• W3100503434 hasConceptScore W3100503434C3013748606 @default.
• W3100503434 hasConceptScore W3100503434C71924100 @default.
• W3100503434 hasIssue "5" @default.
• W3100503434 hasLocation W31005034341 @default.
• W3100503434 hasLocation W31005034342 @default.
• W3100503434 hasOpenAccess W3100503434 @default.
• W3100503434 hasPrimaryLocation W31005034341 @default.
• W3100503434 hasRelatedWork W127131570 @default.
• W3100503434 hasRelatedWork W2325222779 @default.
• W3100503434 hasRelatedWork W2411561522 @default.
• W3100503434 hasRelatedWork W2588715825 @default.
• W3100503434 hasRelatedWork W3000281717 @default.
• W3100503434 hasRelatedWork W3016565612 @default.
• W3100503434 hasRelatedWork W3100503434 @default.
• W3100503434 hasRelatedWork W4281676013 @default.
• W3100503434 hasRelatedWork W4293842501 @default.
• W3100503434 hasRelatedWork W4317999579 @default.
• W3100503434 hasVolume "25" @default.
• W3100503434 isParatext "false" @default.

• next