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• W3100503905 endingPage "117185" @default.
• W3100503905 startingPage "117185" @default.
• W3100503905 abstract "Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex (ALS-PDC) is a disappearing neurodegenerative disorder of apparent environmental origin formerly hyperendemic among Chamorros of Guam-USA, Japanese residents of the Kii Peninsula, Honshu Island, Japan and Auyu-Jakai linguistic groups of Papua-Indonesia on the island of New Guinea. The most plausible etiology is exposure to genotoxins in seed of neurotoxic cycad plants formerly used for food and/or medicine. Primary suspicion falls on methylazoxymethanol (MAM), the aglycone of cycasin and on the non-protein amino acid β-N-methylamino-L-alanine, both of which are metabolized to formaldehyde. Human and animal studies suggest: (a) exposures occurred early in life and sometimes during late fetal brain development, (b) clinical expression of neurodegenerative disease appeared years or decades later, and (c) pathological changes in various tissues indicate the disease was not confined to the CNS. Experimental evidence points to toxic molecular mechanisms involving DNA damage, epigenetic changes, transcriptional mutagenesis, neuronal cell-cycle reactivation and perturbation of the ubiquitin-proteasome system that led to polyproteinopathy and culminated in neuronal degeneration. Lessons learned from research on ALS-PDC include: (a) familial disease may reflect common toxic exposures across generations, (b) primary disease prevention follows cessation of exposure to culpable environmental triggers; and (c) disease latency provides a prolonged period during which to intervene therapeutically. Exposure to genotoxic chemicals (“slow toxins”) in the early stages of life should be considered in the search for the etiology of ALS-PDC-related neurodegenerative disorders, including sporadic forms of ALS, progressive supranuclear palsy and Alzheimer's disease." @default.
• W3100503905 created "2020-11-23" @default.
• W3100503905 creator A5033647153 @default.
• W3100503905 creator A5076619105 @default.
• W3100503905 creator A5085378941 @default.
• W3100503905 date "2020-12-01" @default.
• W3100503905 modified "2023-10-12" @default.
• W3100503905 title "Western Pacific ALS-PDC: Evidence implicating cycad genotoxins" @default.
• W3100503905 cites W114637156 @default.
• W3100503905 cites W1490681631 @default.
• W3100503905 cites W1545354376 @default.
• W3100503905 cites W1553065409 @default.
• W3100503905 cites W1560879547 @default.
• W3100503905 cites W1591021074 @default.
• W3100503905 cites W1805795852 @default.
• W3100503905 cites W1848907877 @default.
• W3100503905 cites W1865940872 @default.
• W3100503905 cites W1875539046 @default.
• W3100503905 cites W1964043050 @default.
• W3100503905 cites W1965558029 @default.
• W3100503905 cites W1965808840 @default.
• W3100503905 cites W1966669150 @default.
• W3100503905 cites W1967195211 @default.
• W3100503905 cites W1972961035 @default.
• W3100503905 cites W1973237516 @default.
• W3100503905 cites W1973502945 @default.
• W3100503905 cites W1974327971 @default.
• W3100503905 cites W1974473730 @default.
• W3100503905 cites W1975171088 @default.
• W3100503905 cites W1975854468 @default.
• W3100503905 cites W1977103757 @default.
• W3100503905 cites W1977144473 @default.
• W3100503905 cites W1978168248 @default.
• W3100503905 cites W1980046499 @default.
• W3100503905 cites W1982852827 @default.
• W3100503905 cites W1983717670 @default.
• W3100503905 cites W1985645379 @default.
• W3100503905 cites W1985778880 @default.
• W3100503905 cites W1987626863 @default.
• W3100503905 cites W1988246803 @default.
• W3100503905 cites W1989063226 @default.
• W3100503905 cites W1989465872 @default.
• W3100503905 cites W1989872039 @default.
• W3100503905 cites W1990030306 @default.
• W3100503905 cites W1990608488 @default.
• W3100503905 cites W1991371609 @default.
• W3100503905 cites W1991582803 @default.
• W3100503905 cites W1991869354 @default.
• W3100503905 cites W1992267182 @default.
• W3100503905 cites W1992780262 @default.
• W3100503905 cites W1993172769 @default.
• W3100503905 cites W1994286733 @default.
• W3100503905 cites W1994925296 @default.
• W3100503905 cites W1994975498 @default.
• W3100503905 cites W1995205529 @default.
• W3100503905 cites W1995422936 @default.
• W3100503905 cites W1996572616 @default.
• W3100503905 cites W1997126124 @default.
• W3100503905 cites W1997188060 @default.
• W3100503905 cites W1998038668 @default.
• W3100503905 cites W1999286013 @default.
• W3100503905 cites W2000616523 @default.
• W3100503905 cites W2000643475 @default.
• W3100503905 cites W2002692118 @default.
• W3100503905 cites W2003396737 @default.
• W3100503905 cites W2003975144 @default.
• W3100503905 cites W2004004906 @default.
• W3100503905 cites W2006410413 @default.
• W3100503905 cites W2006847754 @default.
• W3100503905 cites W2007491812 @default.
• W3100503905 cites W2007868652 @default.
• W3100503905 cites W2008257078 @default.
• W3100503905 cites W2008317554 @default.
• W3100503905 cites W2009189236 @default.
• W3100503905 cites W2009865085 @default.
• W3100503905 cites W2009934111 @default.
• W3100503905 cites W2010652292 @default.
• W3100503905 cites W2011507683 @default.
• W3100503905 cites W2014707045 @default.
• W3100503905 cites W2016462453 @default.
• W3100503905 cites W2018385559 @default.
• W3100503905 cites W2018429553 @default.
• W3100503905 cites W2019707807 @default.
• W3100503905 cites W2021371741 @default.
• W3100503905 cites W2023772093 @default.
• W3100503905 cites W2024337476 @default.
• W3100503905 cites W2026133921 @default.
• W3100503905 cites W2026441295 @default.
• W3100503905 cites W2028491013 @default.
• W3100503905 cites W2029092882 @default.
• W3100503905 cites W2030764183 @default.
• W3100503905 cites W2032195804 @default.
• W3100503905 cites W2032427482 @default.
• W3100503905 cites W2033459798 @default.
• W3100503905 cites W2033657668 @default.
• W3100503905 cites W2034262805 @default.
• W3100503905 cites W2035278970 @default.
• W3100503905 cites W2037235103 @default.

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