FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100506634> ?p ?o ?g. }

• W3100506634 endingPage "104109" @default.
• W3100506634 startingPage "104109" @default.
• W3100506634 abstract "Synthetic biology applications often require engineered computing structures, which can be programmed to process the information in a given way. However, programming of these structures usually requires significant amount of trial-and-error genetic engineering. This process is to some degree analogous to the design of application-specific integrated circuits (ASIC) in the domain of digital electronic circuits, which often require complex and time-consuming workflows to obtain a desired response. We describe a design of programmable biological circuits that can be configured without additional genetic engineering. Their configuration can be changed in vivo, i.e. during the execution of their biological program, simply with an introduction of programming inputs. These, e.g., increase the degradation rates of selected proteins that store the current configuration of the circuit. Programming can be thus performed in the field as in the case of field-programmable gate array (FPGA) circuits, which present an attractive alternative of ASICs in digital electronics. We describe a basic programmable unit, which we denote configurable (bio)logical block (CBLB) inspired by the architecture of configurable logic blocks (CLBs), basic functional units within the FPGA circuits. The design of a CBLB is based on distributed cellular computing modules, which makes its biological implementation easier to achieve. We establish a computational model of a CBLB and analyse its response with a given set of biologically feasible parameter values. Furthermore, we show that the proposed CBLB design exhibits correct behaviour for a vast range of kinetic parameter values, different population ratios, and as well preserves this response in stochastic simulations." @default.
• W3100506634 created "2020-11-23" @default.
• W3100506634 creator A5028092263 @default.
• W3100506634 creator A5032887954 @default.
• W3100506634 creator A5055441247 @default.
• W3100506634 creator A5070333985 @default.
• W3100506634 date "2021-01-01" @default.
• W3100506634 modified "2023-09-23" @default.
• W3100506634 title "Field-programmable biological circuits and configurable (bio)logic blocks for distributed biological computing" @default.
• W3100506634 cites W1926807800 @default.
• W3100506634 cites W1973577260 @default.
• W3100506634 cites W1985161570 @default.
• W3100506634 cites W1991439176 @default.
• W3100506634 cites W2003633481 @default.
• W3100506634 cites W2023525048 @default.
• W3100506634 cites W2027350316 @default.
• W3100506634 cites W2029205241 @default.
• W3100506634 cites W2049648266 @default.
• W3100506634 cites W2053156756 @default.
• W3100506634 cites W2076800072 @default.
• W3100506634 cites W2083983731 @default.
• W3100506634 cites W2090876232 @default.
• W3100506634 cites W2114228460 @default.
• W3100506634 cites W2123992133 @default.
• W3100506634 cites W2134440848 @default.
• W3100506634 cites W2134759932 @default.
• W3100506634 cites W2155344937 @default.
• W3100506634 cites W2155418451 @default.
• W3100506634 cites W2157886837 @default.
• W3100506634 cites W2191007052 @default.
• W3100506634 cites W2264491336 @default.
• W3100506634 cites W2265495650 @default.
• W3100506634 cites W2298762068 @default.
• W3100506634 cites W2382100040 @default.
• W3100506634 cites W2485471172 @default.
• W3100506634 cites W2593052364 @default.
• W3100506634 cites W2593447375 @default.
• W3100506634 cites W2771164439 @default.
• W3100506634 cites W2790962488 @default.
• W3100506634 cites W2793358513 @default.
• W3100506634 cites W2795045314 @default.
• W3100506634 cites W2878721160 @default.
• W3100506634 cites W2942649104 @default.
• W3100506634 cites W2950803758 @default.
• W3100506634 cites W2962032509 @default.
• W3100506634 cites W2974339607 @default.
• W3100506634 cites W3016613127 @default.
• W3100506634 doi "https://doi.org/10.1016/j.compbiomed.2020.104109" @default.
• W3100506634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33221638" @default.
• W3100506634 hasPublicationYear "2021" @default.
• W3100506634 type Work @default.
• W3100506634 sameAs 3100506634 @default.
• W3100506634 citedByCount "2" @default.
• W3100506634 countsByYear W31005066342022 @default.
• W3100506634 countsByYear W31005066342023 @default.
• W3100506634 crossrefType "journal-article" @default.
• W3100506634 hasAuthorship W3100506634A5028092263 @default.
• W3100506634 hasAuthorship W3100506634A5032887954 @default.
• W3100506634 hasAuthorship W3100506634A5055441247 @default.
• W3100506634 hasAuthorship W3100506634A5070333985 @default.
• W3100506634 hasConcept C110332635 @default.
• W3100506634 hasConcept C11413529 @default.
• W3100506634 hasConcept C118524514 @default.
• W3100506634 hasConcept C119599485 @default.
• W3100506634 hasConcept C127413603 @default.
• W3100506634 hasConcept C131017901 @default.
• W3100506634 hasConcept C134146338 @default.
• W3100506634 hasConcept C154945302 @default.
• W3100506634 hasConcept C157922185 @default.
• W3100506634 hasConcept C191908910 @default.
• W3100506634 hasConcept C206274596 @default.
• W3100506634 hasConcept C2524010 @default.
• W3100506634 hasConcept C2777210771 @default.
• W3100506634 hasConcept C33923547 @default.
• W3100506634 hasConcept C41008148 @default.
• W3100506634 hasConcept C42935608 @default.
• W3100506634 hasConcept C60644358 @default.
• W3100506634 hasConcept C77390884 @default.
• W3100506634 hasConcept C81843906 @default.
• W3100506634 hasConcept C86803240 @default.
• W3100506634 hasConcept C9390403 @default.
• W3100506634 hasConceptScore W3100506634C110332635 @default.
• W3100506634 hasConceptScore W3100506634C11413529 @default.
• W3100506634 hasConceptScore W3100506634C118524514 @default.
• W3100506634 hasConceptScore W3100506634C119599485 @default.
• W3100506634 hasConceptScore W3100506634C127413603 @default.
• W3100506634 hasConceptScore W3100506634C131017901 @default.
• W3100506634 hasConceptScore W3100506634C134146338 @default.
• W3100506634 hasConceptScore W3100506634C154945302 @default.
• W3100506634 hasConceptScore W3100506634C157922185 @default.
• W3100506634 hasConceptScore W3100506634C191908910 @default.
• W3100506634 hasConceptScore W3100506634C206274596 @default.
• W3100506634 hasConceptScore W3100506634C2524010 @default.
• W3100506634 hasConceptScore W3100506634C2777210771 @default.
• W3100506634 hasConceptScore W3100506634C33923547 @default.
• W3100506634 hasConceptScore W3100506634C41008148 @default.
• W3100506634 hasConceptScore W3100506634C42935608 @default.
• W3100506634 hasConceptScore W3100506634C60644358 @default.

• next