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• W3100509556 abstract "RNA interference (RNAi) is one of the most promising methods for the treatment of malignant tumors. However, developing an efficient biocompatible delivery vector for small interfering RNA (siRNA) remains a challenging issue. This study aimed to prepare a non-viral tumor-targeted carrier, named RGDfC-modified functionalized selenium nanoparticles (RGDfC-SeNPs). RGDfC-SeNPs were used to selectively deliver siSox2 to HepG2 liver cancer cells and tissues for the treatment of hepatocellular carcinoma (HCC). In the current study, RGDfC-SeNPs were successfully synthesized and characterized. It was shown that RGDfC-SeNPs could effectively load siSox2 to prepare an antitumor prodrug [email protected] [email protected] exhibited selective uptake in HepG2 liver cancer cells and LO2 normal liver cells, indicating RGDfC-SeNPs could effectively deliver siSox2 to HepG2 liver cancer cells. [email protected] entered HepG2 cells via clathrin-mediated endocytosis by firstly encircling the cytoplasm and then releasing siSox2 in the lysosomes. [email protected] could effectively silence Sox2 and inhibit the proliferation, migration and invasion of HepG2 cells. [email protected] induced HepG2 cells apoptosis most likely via overproduction of reactive oxygen species and disruption of the mitochondrial membrane potentials. Most importantly, [email protected] significantly inhibited the tumor growth in HepG2 tumor-bearing mice without obvious toxic side effects. These studies indicated that RGDfC-SeNPs may be an ideal gene carrier for delivering siSox2 to HepG2 cells and that [email protected] may be a novel and highly specific gene-targeted prodrug therapy for HCC." @default.
• W3100509556 created "2020-11-23" @default.
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• W3100509556 date "2021-05-01" @default.
• W3100509556 modified "2023-09-27" @default.
• W3100509556 title "Tumor-targeted delivery of siRNA to silence Sox2 gene expression enhances therapeutic response in hepatocellular carcinoma" @default.
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• W3100509556 doi "https://doi.org/10.1016/j.bioactmat.2020.10.019" @default.
• W3100509556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7658325" @default.
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