FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100511639> ?p ?o ?g. }

• W3100511639 abstract "Abstract COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. There is an urgent need for predictive markers that can guide clinical decision-making, inform about the effect of experimental therapies, and point to novel therapeutic targets. Here, we characterize the time-dependent progression of COVID-19 through different stages of the disease, by measuring 86 accredited diagnostic parameters and plasma proteomes at 687 sampling points, in a cohort of 139 patients during hospitalization. We report that the time-resolved patient molecular phenotypes reflect an initial spike in the systemic inflammatory response, which is gradually alleviated and followed by a protein signature indicative of tissue repair, metabolic reconstitution and immunomodulation. Further, we show that the early host response is predictive for the disease trajectory and gives rise to proteomic and diagnostic marker signatures that classify the need for supplemental oxygen therapy and mechanical ventilation, and that predict the time to recovery of mildly ill patients. In severely ill patients, the molecular phenotype of the early host response predicts survival, in two independent cohorts and weeks before outcome. We also identify age-specific molecular response to COVID-19, which involves increased inflammation and lipoprotein dysregulation in older patients. Our study provides a deep and time resolved molecular characterization of COVID-19 disease progression, and reports biomarkers for risk-adapted treatment strategies and molecular disease monitoring. Our study demonstrates accurate prognosis of COVID-19 outcome from proteomic signatures recorded weeks earlier." @default.
• W3100511639 created "2020-11-23" @default.
• W3100511639 creator A5005365222 @default.
• W3100511639 creator A5007057301 @default.
• W3100511639 creator A5007256008 @default.
• W3100511639 creator A5009077999 @default.
• W3100511639 creator A5012172684 @default.
• W3100511639 creator A5013048344 @default.
• W3100511639 creator A5017328820 @default.
• W3100511639 creator A5020418534 @default.
• W3100511639 creator A5021463697 @default.
• W3100511639 creator A5025207344 @default.
• W3100511639 creator A5026954665 @default.
• W3100511639 creator A5027744537 @default.
• W3100511639 creator A5028816041 @default.
• W3100511639 creator A5030859165 @default.
• W3100511639 creator A5030917553 @default.
• W3100511639 creator A5032232791 @default.
• W3100511639 creator A5034699200 @default.
• W3100511639 creator A5038382199 @default.
• W3100511639 creator A5040014427 @default.
• W3100511639 creator A5040615109 @default.
• W3100511639 creator A5040888641 @default.
• W3100511639 creator A5040973193 @default.
• W3100511639 creator A5041423154 @default.
• W3100511639 creator A5041605955 @default.
• W3100511639 creator A5043863247 @default.
• W3100511639 creator A5044586545 @default.
• W3100511639 creator A5045835301 @default.
• W3100511639 creator A5046831274 @default.
• W3100511639 creator A5048444402 @default.
• W3100511639 creator A5049633865 @default.
• W3100511639 creator A5050176456 @default.
• W3100511639 creator A5052935564 @default.
• W3100511639 creator A5053301339 @default.
• W3100511639 creator A5055071073 @default.
• W3100511639 creator A5056857104 @default.
• W3100511639 creator A5057254396 @default.
• W3100511639 creator A5058728720 @default.
• W3100511639 creator A5062339030 @default.
• W3100511639 creator A5064669907 @default.
• W3100511639 creator A5066327445 @default.
• W3100511639 creator A5066436360 @default.
• W3100511639 creator A5067716705 @default.
• W3100511639 creator A5068503425 @default.
• W3100511639 creator A5068516063 @default.
• W3100511639 creator A5070298014 @default.
• W3100511639 creator A5070892021 @default.
• W3100511639 creator A5073744066 @default.
• W3100511639 creator A5074432363 @default.
• W3100511639 creator A5074559236 @default.
• W3100511639 creator A5074607200 @default.
• W3100511639 creator A5075257395 @default.
• W3100511639 creator A5077556446 @default.
• W3100511639 creator A5077692993 @default.
• W3100511639 creator A5077909901 @default.
• W3100511639 creator A5078573233 @default.
• W3100511639 creator A5084175530 @default.
• W3100511639 creator A5084600026 @default.
• W3100511639 creator A5087602254 @default.
• W3100511639 creator A5088680222 @default.
• W3100511639 creator A5090713065 @default.
• W3100511639 creator A5091593739 @default.
• W3100511639 date "2020-11-12" @default.
• W3100511639 modified "2023-10-03" @default.
• W3100511639 title "A time-resolved proteomic and diagnostic map characterizes COVID-19 disease progression and predicts outcome" @default.
• W3100511639 cites W1541849094 @default.
• W3100511639 cites W1543429526 @default.
• W3100511639 cites W158326603 @default.
• W3100511639 cites W1608564964 @default.
• W3100511639 cites W1803784511 @default.
• W3100511639 cites W1971275647 @default.
• W3100511639 cites W1976588449 @default.
• W3100511639 cites W1979169292 @default.
• W3100511639 cites W1991081852 @default.
• W3100511639 cites W1992431343 @default.
• W3100511639 cites W1994340768 @default.
• W3100511639 cites W1994501461 @default.
• W3100511639 cites W1997552453 @default.
• W3100511639 cites W2016593129 @default.
• W3100511639 cites W2025339373 @default.
• W3100511639 cites W2053636564 @default.
• W3100511639 cites W2079843936 @default.
• W3100511639 cites W2081098333 @default.
• W3100511639 cites W2082052614 @default.
• W3100511639 cites W2097708776 @default.
• W3100511639 cites W2098432330 @default.
• W3100511639 cites W2107030820 @default.
• W3100511639 cites W2110065044 @default.
• W3100511639 cites W2140307349 @default.
• W3100511639 cites W2145899814 @default.
• W3100511639 cites W2146512944 @default.
• W3100511639 cites W2149784485 @default.
• W3100511639 cites W2167090025 @default.
• W3100511639 cites W2170776626 @default.
• W3100511639 cites W2173367702 @default.
• W3100511639 cites W2262749210 @default.
• W3100511639 cites W2280404143 @default.
• W3100511639 cites W2469090867 @default.
• W3100511639 cites W2482726968 @default.

• next