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- W3100540000 abstract "A novel lectin was purified from newly cyanobacterium isolate, Oscillatoria acuminate MHM-632 MK014210.1 using affinity chromatography with a molecular weight of 120 kDa under native-PAGE and 30 kDa on reducing-PAGE, represented tetramer nature of this lectin. Oscillatorial lectin showed stability at 60 °C for 30 min, pH-dependent, with the highest activities over the pH range of 6-8, and required zinc ions to express its full activity. Oscillatorial lectin is a glycan-binding protein with a neutral carbohydrate content of 7.0% as evaluated by the phenol-sulfuric acid method. Polyols and α- glycosides polymer of mannose sugar or sugars alcohol were completely inhibited oscillatorial lectin with MIC of 0.195 mM, while β-glycosides sugars did not show any inhibition effect. The oscillatorial lectin has anti-proliferative activity against Huh-7 and MCF-7 cancer cells and inhibited their proliferation with EC50 values of 106.75 µg/ml and 254.14 µg/ml, respectively. Besides the anticancer effect, oscillatorial lectin also has potent antiviral activity against HSV-1 in a dose-dependent manner via virions neutralization and inhibition of viral replication with IC50 values of 90.95 ng/ml and 131.3 ng/ml, respectively. The unique carbohydrate affinity of oscillatorial lectin provides insight into its use as a promising candidate in many biotechnological applications, like fighting viral infection and combating cancer disease.Communicated by Ramaswamy H. Sarma." @default.
- W3100540000 created "2020-11-23" @default.
- W3100540000 creator A5025470334 @default.
- W3100540000 creator A5033704852 @default.
- W3100540000 creator A5075379676 @default.
- W3100540000 creator A5082250847 @default.
- W3100540000 date "2020-11-17" @default.
- W3100540000 modified "2023-10-16" @default.
- W3100540000 title "<i>In vitro</i> assessment of dual (antiviral and antitumor) activity of a novel lectin produced by the newly cyanobacterium isolate, <i>Oscillatoria acuminate</i> MHM-632 MK014210.1" @default.
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- W3100540000 doi "https://doi.org/10.1080/07391102.2020.1848632" @default.