Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100541625> ?p ?o ?g. }
- W3100541625 endingPage "453" @default.
- W3100541625 startingPage "453" @default.
- W3100541625 abstract "Electrophilic small molecules have gained significant attention over the last decade in the field of covalent drug discovery. Long recognized as mediators of the inflammatory process, recent evidence suggests that electrophiles may modulate the immune response through the regulation of metabolic networks. These molecules function as pleiotropic signaling mediators capable of reversibly reacting with nucleophilic biomolecules, most notably at reactive cysteines. More specifically, electrophiles target critical cysteines in redox regulatory proteins to activate protective pathways such as the nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 (Nrf2-Keap1) antioxidant signaling pathway while also inhibiting Nuclear Factor κB (NF-κB). During inflammatory states, reactive species broadly alter cell signaling through the oxidation of lipids, amino acids, and nucleic acids, effectively propagating the inflammatory sequence. Subsequent changes in metabolic signaling inform immune cell maturation and effector function. Therapeutic strategies targeting inflammatory pathologies leverage electrophilic drug compounds, in part, because of their documented effect on the redox balance of the cell. With mounting evidence demonstrating the link between redox signaling and metabolism, electrophiles represent ideal therapeutic candidates for the treatment of inflammatory conditions. Through their pleiotropic signaling activity, electrophiles may be used strategically to both directly and indirectly target immune cell metabolism." @default.
- W3100541625 created "2020-11-23" @default.
- W3100541625 creator A5037793417 @default.
- W3100541625 creator A5048707762 @default.
- W3100541625 date "2020-11-10" @default.
- W3100541625 modified "2023-10-16" @default.
- W3100541625 title "Electrophile Modulation of Inflammation: A Two-Hit Approach" @default.
- W3100541625 cites W1507326555 @default.
- W3100541625 cites W1559974225 @default.
- W3100541625 cites W1571368642 @default.
- W3100541625 cites W1578356299 @default.
- W3100541625 cites W1622211725 @default.
- W3100541625 cites W1766122222 @default.
- W3100541625 cites W1812573520 @default.
- W3100541625 cites W1874765914 @default.
- W3100541625 cites W1938274351 @default.
- W3100541625 cites W1964500675 @default.
- W3100541625 cites W1964828595 @default.
- W3100541625 cites W1967077010 @default.
- W3100541625 cites W1967143550 @default.
- W3100541625 cites W1969321910 @default.
- W3100541625 cites W1971243875 @default.
- W3100541625 cites W1974332498 @default.
- W3100541625 cites W1976209276 @default.
- W3100541625 cites W1978094617 @default.
- W3100541625 cites W1978287335 @default.
- W3100541625 cites W1980065583 @default.
- W3100541625 cites W1980734840 @default.
- W3100541625 cites W1985871840 @default.
- W3100541625 cites W1989090840 @default.
- W3100541625 cites W1989467711 @default.
- W3100541625 cites W1990014836 @default.
- W3100541625 cites W1993635466 @default.
- W3100541625 cites W1994998355 @default.
- W3100541625 cites W1997745709 @default.
- W3100541625 cites W2000198750 @default.
- W3100541625 cites W2000323986 @default.
- W3100541625 cites W2002051280 @default.
- W3100541625 cites W2003975298 @default.
- W3100541625 cites W2003993652 @default.
- W3100541625 cites W2004815940 @default.
- W3100541625 cites W2005002977 @default.
- W3100541625 cites W2005211913 @default.
- W3100541625 cites W2005293673 @default.
- W3100541625 cites W2007636933 @default.
- W3100541625 cites W2008004470 @default.
- W3100541625 cites W2009911964 @default.
- W3100541625 cites W2010208657 @default.
- W3100541625 cites W2011866187 @default.
- W3100541625 cites W2013150924 @default.
- W3100541625 cites W2014687097 @default.
- W3100541625 cites W2015243552 @default.
- W3100541625 cites W2015392958 @default.
- W3100541625 cites W2015644600 @default.
- W3100541625 cites W2016008825 @default.
- W3100541625 cites W2016535776 @default.
- W3100541625 cites W2023459898 @default.
- W3100541625 cites W2028769116 @default.
- W3100541625 cites W2030969794 @default.
- W3100541625 cites W2031084334 @default.
- W3100541625 cites W2032624312 @default.
- W3100541625 cites W2034713072 @default.
- W3100541625 cites W2035211778 @default.
- W3100541625 cites W2035676834 @default.
- W3100541625 cites W2042149164 @default.
- W3100541625 cites W2045050366 @default.
- W3100541625 cites W2045631219 @default.
- W3100541625 cites W2046128399 @default.
- W3100541625 cites W2053047691 @default.
- W3100541625 cites W2056073338 @default.
- W3100541625 cites W2057627073 @default.
- W3100541625 cites W2059543451 @default.
- W3100541625 cites W2059545411 @default.
- W3100541625 cites W2061623879 @default.
- W3100541625 cites W2061676392 @default.
- W3100541625 cites W2063025076 @default.
- W3100541625 cites W2064205139 @default.
- W3100541625 cites W2065147201 @default.
- W3100541625 cites W2065474006 @default.
- W3100541625 cites W2066699861 @default.
- W3100541625 cites W2066817189 @default.
- W3100541625 cites W2070392932 @default.
- W3100541625 cites W2071792689 @default.
- W3100541625 cites W2073568014 @default.
- W3100541625 cites W2077561082 @default.
- W3100541625 cites W2078995073 @default.
- W3100541625 cites W2081674053 @default.
- W3100541625 cites W2090609282 @default.
- W3100541625 cites W2092842004 @default.
- W3100541625 cites W2094803175 @default.
- W3100541625 cites W2095539444 @default.
- W3100541625 cites W2099792161 @default.
- W3100541625 cites W2101641567 @default.
- W3100541625 cites W2109621677 @default.
- W3100541625 cites W2113274715 @default.
- W3100541625 cites W2116699776 @default.
- W3100541625 cites W2117800935 @default.
- W3100541625 cites W2120807382 @default.