FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100556428> ?p ?o ?g. }

• W3100556428 endingPage "980" @default.
• W3100556428 startingPage "971" @default.
• W3100556428 abstract "Regulatory T cells may serve as targets in cancer immunotherapy. A previous study showed that the chemokine CCL17 and the receptor CCR4 play roles in regulatory T cell recruitment in canine urothelial carcinoma. In this article, we show that the BRAFV595E mutation is associated with tumor-produced CCL17 and regulatory T cell infiltration in dogs with urothelial carcinoma. In comparison with healthy dogs, dogs with urothelial carcinoma showed increased CCL17 mRNA expression in the bladder and elevated CCL17 protein concentration in urine. Immunohistochemistry showed increased levels of Foxp3+ regulatory T cells in the tumor tissues of urothelial carcinoma. The density of Foxp3+ regulatory T cells was positively correlated with CCL17 concentration in urine, indicating that CCL17 is involved in regulatory T cell recruitment. Moreover, tumor-infiltrating regulatory T cells and urine CCL17 concentration were associated with poor prognosis in dogs with urothelial carcinoma. The number of tumor-infiltrating regulatory T cells, CCL17 mRNA expression, and urine CCL17 concentration in cases with BRAFV595E mutation were higher than those in cases with wild-type BRAF. In vitro, high CCL17 production was detected in a canine urothelial carcinoma cell line with BRAFV595E mutation but not in an urothelial carcinoma cell line with wild-type BRAF. Dabrafenib, a BRAF inhibitor, decreased CCL17 production in the cell line with BRAFV595E mutation. These results suggest that BRAFV595E mutation induced CCL17 production and contributed to regulatory T cell recruitment in canine urothelial carcinoma." @default.
• W3100556428 created "2020-11-23" @default.
• W3100556428 creator A5004893002 @default.
• W3100556428 creator A5008386981 @default.
• W3100556428 creator A5011620586 @default.
• W3100556428 creator A5029806948 @default.
• W3100556428 creator A5033262704 @default.
• W3100556428 creator A5035597190 @default.
• W3100556428 creator A5043175205 @default.
• W3100556428 creator A5045947281 @default.
• W3100556428 creator A5056807675 @default.
• W3100556428 creator A5075177946 @default.
• W3100556428 creator A5084255017 @default.
• W3100556428 date "2020-11-18" @default.
• W3100556428 modified "2023-10-03" @default.
• W3100556428 title "BRAF^V595E Mutation Associates CCL17 Expression and Regulatory T Cell Recruitment in Urothelial Carcinoma of Dogs" @default.
• W3100556428 cites W1537488767 @default.
• W3100556428 cites W1557973478 @default.
• W3100556428 cites W1897439566 @default.
• W3100556428 cites W1975839407 @default.
• W3100556428 cites W2001333940 @default.
• W3100556428 cites W2027542963 @default.
• W3100556428 cites W2030375512 @default.
• W3100556428 cites W2033687485 @default.
• W3100556428 cites W2047023073 @default.
• W3100556428 cites W2049491375 @default.
• W3100556428 cites W2055773606 @default.
• W3100556428 cites W2056921894 @default.
• W3100556428 cites W2064782617 @default.
• W3100556428 cites W2067897593 @default.
• W3100556428 cites W2070755789 @default.
• W3100556428 cites W2080719056 @default.
• W3100556428 cites W2085014380 @default.
• W3100556428 cites W2085294065 @default.
• W3100556428 cites W2099540110 @default.
• W3100556428 cites W2099842835 @default.
• W3100556428 cites W2102557111 @default.
• W3100556428 cites W2103675014 @default.
• W3100556428 cites W2120276871 @default.
• W3100556428 cites W2122722532 @default.
• W3100556428 cites W2147250941 @default.
• W3100556428 cites W2149673009 @default.
• W3100556428 cites W2151014103 @default.
• W3100556428 cites W2151351958 @default.
• W3100556428 cites W2158629604 @default.
• W3100556428 cites W2163188200 @default.
• W3100556428 cites W2168143310 @default.
• W3100556428 cites W2169963604 @default.
• W3100556428 cites W2195692730 @default.
• W3100556428 cites W2290435614 @default.
• W3100556428 cites W2585370594 @default.
• W3100556428 cites W2727188188 @default.
• W3100556428 cites W2766878224 @default.
• W3100556428 cites W2782685657 @default.
• W3100556428 cites W2801384602 @default.
• W3100556428 cites W2884395150 @default.
• W3100556428 cites W2907134368 @default.
• W3100556428 cites W2909337470 @default.
• W3100556428 cites W2938280489 @default.
• W3100556428 cites W2948101448 @default.
• W3100556428 cites W2950122676 @default.
• W3100556428 cites W3017926227 @default.
• W3100556428 cites W3022901606 @default.
• W3100556428 cites W4251638272 @default.
• W3100556428 cites W569838262 @default.
• W3100556428 doi "https://doi.org/10.1177/0300985820967449" @default.
• W3100556428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33205710" @default.
• W3100556428 hasPublicationYear "2020" @default.
• W3100556428 type Work @default.
• W3100556428 sameAs 3100556428 @default.
• W3100556428 citedByCount "7" @default.
• W3100556428 countsByYear W31005564282021 @default.
• W3100556428 countsByYear W31005564282022 @default.
• W3100556428 countsByYear W31005564282023 @default.
• W3100556428 crossrefType "journal-article" @default.
• W3100556428 hasAuthorship W3100556428A5004893002 @default.
• W3100556428 hasAuthorship W3100556428A5008386981 @default.
• W3100556428 hasAuthorship W3100556428A5011620586 @default.
• W3100556428 hasAuthorship W3100556428A5029806948 @default.
• W3100556428 hasAuthorship W3100556428A5033262704 @default.
• W3100556428 hasAuthorship W3100556428A5035597190 @default.
• W3100556428 hasAuthorship W3100556428A5043175205 @default.
• W3100556428 hasAuthorship W3100556428A5045947281 @default.
• W3100556428 hasAuthorship W3100556428A5056807675 @default.
• W3100556428 hasAuthorship W3100556428A5075177946 @default.
• W3100556428 hasAuthorship W3100556428A5084255017 @default.
• W3100556428 hasConcept C12823836 @default.
• W3100556428 hasConcept C13373296 @default.
• W3100556428 hasConcept C143172330 @default.
• W3100556428 hasConcept C16930146 @default.
• W3100556428 hasConcept C203014093 @default.
• W3100556428 hasConcept C2775922572 @default.
• W3100556428 hasConcept C2776914184 @default.
• W3100556428 hasConcept C2779727006 @default.
• W3100556428 hasConcept C37307934 @default.
• W3100556428 hasConcept C502942594 @default.
• W3100556428 hasConcept C71924100 @default.
• W3100556428 hasConcept C86803240 @default.

• next