Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100556461> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3100556461 endingPage "e0241989" @default.
- W3100556461 startingPage "e0241989" @default.
- W3100556461 abstract "Introduction Eculizumab is a licensed treatment for several rare, complement-mediated diseases. Eculizumab use is associated with an approximately 2,000-fold increased meningococcal disease risk. In the United States, meningococcal vaccines are recommended for eculizumab recipients but there are no recommendations on use of long-term antibiotic prophylaxis. We describe characteristics of and meningococcal vaccine and antibiotic receipt in U.S. eculizumab recipients to inform meningococcal disease prevention strategies. Methods Persons in the IBM® MarketScan® Research Databases with ≥1 claim for eculizumab injection during 2007–2017 were included. Indication for eculizumab use, meningococcal vaccine receipt, and antibiotic receipt were assessed using International Classification of Diseases-9/10 diagnosis codes, vaccine administration procedure codes, and antibiotic codes from pharmacy claims, respectively. Results Overall 696 persons met the inclusion criteria. Paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) were the most common indications for eculizumab use (41% and 37%, respectively); 20% had an undetermined indication. From June 2015 through December 2017, 28% (41/148) of continuously-enrolled patients received ≥1 serogroup B vaccine dose. For serogroup ACWY conjugate vaccine, 45% (91/201) of patients received ≥1 dose within five years of their most recent eculizumab dose, as recommended. Of eculizumab recipients with outpatient prescription data, 7% (41/579) received antibiotics for ≥50% of the period of increased risk for meningococcal disease. Conclusion Many eculizumab recipients had an undetermined indication for eculizumab use; few were up-to-date for recommended meningococcal vaccines or were prescribed antibiotics long-term. These findings can inform further investigation of how to best protect this population from meningococcal disease." @default.
- W3100556461 created "2020-11-23" @default.
- W3100556461 creator A5007812243 @default.
- W3100556461 creator A5020541447 @default.
- W3100556461 creator A5073217960 @default.
- W3100556461 date "2020-11-12" @default.
- W3100556461 modified "2023-09-27" @default.
- W3100556461 title "Characteristics of and meningococcal disease prevention strategies for commercially insured persons receiving eculizumab in the United States" @default.
- W3100556461 cites W1973644206 @default.
- W3100556461 cites W2121920823 @default.
- W3100556461 cites W2126092981 @default.
- W3100556461 cites W2134914390 @default.
- W3100556461 cites W2134940901 @default.
- W3100556461 cites W2171068466 @default.
- W3100556461 cites W2289432387 @default.
- W3100556461 cites W2322926928 @default.
- W3100556461 cites W2614791403 @default.
- W3100556461 cites W2730107276 @default.
- W3100556461 cites W2744554341 @default.
- W3100556461 cites W2782047492 @default.
- W3100556461 cites W2795773120 @default.
- W3100556461 cites W2807740363 @default.
- W3100556461 cites W2900165457 @default.
- W3100556461 cites W2901128710 @default.
- W3100556461 cites W2913199217 @default.
- W3100556461 cites W2914487156 @default.
- W3100556461 cites W2914587352 @default.
- W3100556461 doi "https://doi.org/10.1371/journal.pone.0241989" @default.
- W3100556461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7660549" @default.
- W3100556461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33180804" @default.
- W3100556461 hasPublicationYear "2020" @default.
- W3100556461 type Work @default.
- W3100556461 sameAs 3100556461 @default.
- W3100556461 citedByCount "5" @default.
- W3100556461 countsByYear W31005564612021 @default.
- W3100556461 countsByYear W31005564612022 @default.
- W3100556461 countsByYear W31005564612023 @default.
- W3100556461 crossrefType "journal-article" @default.
- W3100556461 hasAuthorship W3100556461A5007812243 @default.
- W3100556461 hasAuthorship W3100556461A5020541447 @default.
- W3100556461 hasAuthorship W3100556461A5073217960 @default.
- W3100556461 hasBestOaLocation W31005564611 @default.
- W3100556461 hasConcept C111684460 @default.
- W3100556461 hasConcept C126322002 @default.
- W3100556461 hasConcept C159654299 @default.
- W3100556461 hasConcept C177713679 @default.
- W3100556461 hasConcept C187212893 @default.
- W3100556461 hasConcept C203014093 @default.
- W3100556461 hasConcept C2776645655 @default.
- W3100556461 hasConcept C2777346216 @default.
- W3100556461 hasConcept C2777991916 @default.
- W3100556461 hasConcept C2778458888 @default.
- W3100556461 hasConcept C2780454893 @default.
- W3100556461 hasConcept C2780801004 @default.
- W3100556461 hasConcept C501593827 @default.
- W3100556461 hasConcept C523546767 @default.
- W3100556461 hasConcept C54355233 @default.
- W3100556461 hasConcept C71924100 @default.
- W3100556461 hasConcept C86803240 @default.
- W3100556461 hasConcept C89423630 @default.
- W3100556461 hasConceptScore W3100556461C111684460 @default.
- W3100556461 hasConceptScore W3100556461C126322002 @default.
- W3100556461 hasConceptScore W3100556461C159654299 @default.
- W3100556461 hasConceptScore W3100556461C177713679 @default.
- W3100556461 hasConceptScore W3100556461C187212893 @default.
- W3100556461 hasConceptScore W3100556461C203014093 @default.
- W3100556461 hasConceptScore W3100556461C2776645655 @default.
- W3100556461 hasConceptScore W3100556461C2777346216 @default.
- W3100556461 hasConceptScore W3100556461C2777991916 @default.
- W3100556461 hasConceptScore W3100556461C2778458888 @default.
- W3100556461 hasConceptScore W3100556461C2780454893 @default.
- W3100556461 hasConceptScore W3100556461C2780801004 @default.
- W3100556461 hasConceptScore W3100556461C501593827 @default.
- W3100556461 hasConceptScore W3100556461C523546767 @default.
- W3100556461 hasConceptScore W3100556461C54355233 @default.
- W3100556461 hasConceptScore W3100556461C71924100 @default.
- W3100556461 hasConceptScore W3100556461C86803240 @default.
- W3100556461 hasConceptScore W3100556461C89423630 @default.
- W3100556461 hasIssue "11" @default.
- W3100556461 hasLocation W31005564611 @default.
- W3100556461 hasLocation W31005564612 @default.
- W3100556461 hasOpenAccess W3100556461 @default.
- W3100556461 hasPrimaryLocation W31005564611 @default.
- W3100556461 hasRelatedWork W2548746084 @default.
- W3100556461 hasRelatedWork W2582849320 @default.
- W3100556461 hasRelatedWork W2795773120 @default.
- W3100556461 hasRelatedWork W2807433664 @default.
- W3100556461 hasRelatedWork W2810721991 @default.
- W3100556461 hasRelatedWork W2987788695 @default.
- W3100556461 hasRelatedWork W3048185747 @default.
- W3100556461 hasRelatedWork W3095157088 @default.
- W3100556461 hasRelatedWork W3100556461 @default.
- W3100556461 hasRelatedWork W3204693953 @default.
- W3100556461 hasVolume "15" @default.
- W3100556461 isParatext "false" @default.
- W3100556461 isRetracted "false" @default.
- W3100556461 magId "3100556461" @default.
- W3100556461 workType "article" @default.