Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100561706> ?p ?o ?g. }
- W3100561706 endingPage "6636" @default.
- W3100561706 startingPage "6626" @default.
- W3100561706 abstract "Colorectal (CRC) and gastric (GC) cancers are associated with increased morbidity and mortality. Single nucleotide polymorphisms (SNPs) of xenobiotic metabolism and transporter genes may play a role in the individual responses to exposure to substances implicated in susceptibility to cancer. The investigation of the genetic variation related to the activation and detoxification of xenobiotics may thus help to clarify the prevalence of neoplasms. We analyzed the role of 30 SNPs in xenobiotic-metabolizing and transporter genes in susceptibility to CRC and GC. The study included individuals diagnosed with CRC (n = 121) and GC (n = 95), and 141 controls (non-cancer patients) from the population of Belém, in the Brazilian Amazon. The results indicated an association between the polymorphisms rs2231142 (P = 0.013; OR = 3.01; 95% CI = 1.26-7.13), in the ABCG2 gene, and rs1801159 (P = 0.03; OR = 2.35; 95% CI = 1.14-5.05), in DPYD gene, with the risk of developing GC. The polymorphism rs17116806 of the DPYD gene was found to be associated with a lower risk of developing gastric (P≤0.0001; OR = 0.043; 95% CI = 0.015-0.12) or colorectal (P≤0.0001; OR = 0.076; 95% CI = 0.33-0.18) cancers, indicating that the same variant may play a similar role in different types of cancer tissue. Additionally, the carriers of the TT genotype of the polymorphism in the ABCB1 gene (rs1128503) presented a reduced probability of developing CRC (P = 0.0001; OR = 0.16; 95% CI = 0.06-0.41) as well as GC (P = 0.007; OR = 0.27; 95% CI = 0.1-0.7). Our findings indicate that polymorphisms in xenobiotic-metabolizing and transporter genes may modulate susceptibility to colorectal and gastric cancers." @default.
- W3100561706 created "2020-11-23" @default.
- W3100561706 creator A5003582474 @default.
- W3100561706 creator A5022733444 @default.
- W3100561706 creator A5023416409 @default.
- W3100561706 creator A5043326369 @default.
- W3100561706 creator A5049053152 @default.
- W3100561706 creator A5051953427 @default.
- W3100561706 creator A5073795818 @default.
- W3100561706 creator A5078703686 @default.
- W3100561706 creator A5086152020 @default.
- W3100561706 creator A5088866768 @default.
- W3100561706 date "2020-01-01" @default.
- W3100561706 modified "2023-09-26" @default.
- W3100561706 title "Polymorphisms of xenobiotic-metabolizing and transporter genes, and the risk of gastric and colorectal cancer in an admixed population from the Brazilian Amazon." @default.
- W3100561706 cites W1561593600 @default.
- W3100561706 cites W1612923734 @default.
- W3100561706 cites W1614612384 @default.
- W3100561706 cites W2008424186 @default.
- W3100561706 cites W2016271344 @default.
- W3100561706 cites W2018622945 @default.
- W3100561706 cites W2020299878 @default.
- W3100561706 cites W2035635857 @default.
- W3100561706 cites W2048729835 @default.
- W3100561706 cites W2053127406 @default.
- W3100561706 cites W2053371603 @default.
- W3100561706 cites W2076529153 @default.
- W3100561706 cites W2093667591 @default.
- W3100561706 cites W2098052604 @default.
- W3100561706 cites W2098535901 @default.
- W3100561706 cites W2139249154 @default.
- W3100561706 cites W2140496932 @default.
- W3100561706 cites W2143772821 @default.
- W3100561706 cites W2145793412 @default.
- W3100561706 cites W2165918430 @default.
- W3100561706 cites W2166170039 @default.
- W3100561706 cites W2169677962 @default.
- W3100561706 cites W2185705523 @default.
- W3100561706 cites W2260446271 @default.
- W3100561706 cites W2270829663 @default.
- W3100561706 cites W2278760390 @default.
- W3100561706 cites W2409622058 @default.
- W3100561706 cites W2517348335 @default.
- W3100561706 cites W2560180043 @default.
- W3100561706 cites W2564042708 @default.
- W3100561706 cites W2604024577 @default.
- W3100561706 cites W2740881191 @default.
- W3100561706 cites W2755722428 @default.
- W3100561706 cites W2768519606 @default.
- W3100561706 cites W2771019372 @default.
- W3100561706 cites W2776025480 @default.
- W3100561706 cites W2790331199 @default.
- W3100561706 cites W2806504012 @default.
- W3100561706 cites W2887040813 @default.
- W3100561706 cites W2889646458 @default.
- W3100561706 cites W2890944716 @default.
- W3100561706 cites W2922253340 @default.
- W3100561706 cites W2923472491 @default.
- W3100561706 cites W2934527592 @default.
- W3100561706 cites W325740806 @default.
- W3100561706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7653561" @default.
- W3100561706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33194059" @default.
- W3100561706 hasPublicationYear "2020" @default.
- W3100561706 type Work @default.
- W3100561706 sameAs 3100561706 @default.
- W3100561706 citedByCount "3" @default.
- W3100561706 countsByYear W31005617062022 @default.
- W3100561706 countsByYear W31005617062023 @default.
- W3100561706 crossrefType "journal-article" @default.
- W3100561706 hasAuthorship W3100561706A5003582474 @default.
- W3100561706 hasAuthorship W3100561706A5022733444 @default.
- W3100561706 hasAuthorship W3100561706A5023416409 @default.
- W3100561706 hasAuthorship W3100561706A5043326369 @default.
- W3100561706 hasAuthorship W3100561706A5049053152 @default.
- W3100561706 hasAuthorship W3100561706A5051953427 @default.
- W3100561706 hasAuthorship W3100561706A5073795818 @default.
- W3100561706 hasAuthorship W3100561706A5078703686 @default.
- W3100561706 hasAuthorship W3100561706A5086152020 @default.
- W3100561706 hasAuthorship W3100561706A5088866768 @default.
- W3100561706 hasConcept C104317684 @default.
- W3100561706 hasConcept C115448650 @default.
- W3100561706 hasConcept C121608353 @default.
- W3100561706 hasConcept C126322002 @default.
- W3100561706 hasConcept C135763542 @default.
- W3100561706 hasConcept C139275648 @default.
- W3100561706 hasConcept C143998085 @default.
- W3100561706 hasConcept C153209595 @default.
- W3100561706 hasConcept C170734499 @default.
- W3100561706 hasConcept C181199279 @default.
- W3100561706 hasConcept C2779655350 @default.
- W3100561706 hasConcept C2908647359 @default.
- W3100561706 hasConcept C526805850 @default.
- W3100561706 hasConcept C54355233 @default.
- W3100561706 hasConcept C55493867 @default.
- W3100561706 hasConcept C55775858 @default.
- W3100561706 hasConcept C71924100 @default.
- W3100561706 hasConcept C86803240 @default.
- W3100561706 hasConcept C90924648 @default.