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• W3100563362 abstract "The radiation fields in space define tangible risks to the health of astronauts, and significant work in rodent models has clearly shown a variety of exposure paradigms to compromise CNS functionality. Despite our current knowledge, sex differences regarding the risks of space radiation exposure on cognitive function remain poorly understood which is potentially problematic given that thirty percent of astronauts are women. While work from us and others have demonstrated pronounced cognitive decrements in male mice exposed to charged particle irradiation, here we show that female mice exhibit significant resistance to adverse neurocognitive effects of space radiation. Present findings indicate that male mice exposed to low doses (≤ 30 cGy) of energetic (400 MeV/n) helium ions (4He) show significantly higher levels of neuroinflammation and more extensive cognitive deficits than females. Twelve weeks following 4He ion exposure irradiated male mice demonstrated significant deficits in object and place recognition memory accompanied by activation of microglia, marked upregulation of hippocampal Toll-like receptor 4 (TLR4) and increased expression of the pro-inflammatory marker high mobility group box 1 protein (HMGB1). Additionally, we determined that exposure to 4He ions caused a significant decline in the number of dendritic branch points and total dendritic length along with the hippocampus neurons in female mice. Interestingly, only male mice showed a significant decline of dendritic spine density following irradiation. These data indicate that fundamental differences in inflammatory cascades between male and female mice may drive divergent CNS radiation responses that differentially impact the structural plasticity of neurons and neurocognitive outcomes following cosmic radiation exposure." @default.
• W3100563362 created "2020-11-23" @default.
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• W3100563362 date "2020-09-16" @default.
• W3100563362 modified "2023-10-10" @default.
• W3100563362 title "Sex-Specific Cognitive Deficits Following Space Radiation Exposure" @default.
• W3100563362 cites W171118067 @default.
• W3100563362 cites W181798272 @default.
• W3100563362 cites W1967912747 @default.
• W3100563362 cites W1969891837 @default.
• W3100563362 cites W1975432831 @default.
• W3100563362 cites W2003208985 @default.
• W3100563362 cites W2009187132 @default.
• W3100563362 cites W2011566601 @default.
• W3100563362 cites W2019863741 @default.
• W3100563362 cites W2022981588 @default.
• W3100563362 cites W2022990659 @default.
• W3100563362 cites W2079775386 @default.
• W3100563362 cites W2082273382 @default.
• W3100563362 cites W2086118086 @default.
• W3100563362 cites W2094522722 @default.
• W3100563362 cites W2095056606 @default.
• W3100563362 cites W2103630777 @default.
• W3100563362 cites W2115617484 @default.
• W3100563362 cites W2117022355 @default.
• W3100563362 cites W2117338753 @default.
• W3100563362 cites W2121493243 @default.
• W3100563362 cites W2124365311 @default.
• W3100563362 cites W2127587930 @default.
• W3100563362 cites W2130500368 @default.
• W3100563362 cites W2141187954 @default.
• W3100563362 cites W2144531560 @default.
• W3100563362 cites W2150088372 @default.
• W3100563362 cites W2150871836 @default.
• W3100563362 cites W2154663804 @default.
• W3100563362 cites W2164237670 @default.
• W3100563362 cites W2173225193 @default.
• W3100563362 cites W2173820276 @default.
• W3100563362 cites W2190662555 @default.
• W3100563362 cites W2206501781 @default.
• W3100563362 cites W2238060985 @default.
• W3100563362 cites W2291618670 @default.
• W3100563362 cites W2315774119 @default.
• W3100563362 cites W2323047896 @default.
• W3100563362 cites W2419356421 @default.
• W3100563362 cites W2507620027 @default.
• W3100563362 cites W2514294261 @default.
• W3100563362 cites W2529882214 @default.
• W3100563362 cites W2531611143 @default.
• W3100563362 cites W2549778867 @default.
• W3100563362 cites W2553184470 @default.
• W3100563362 cites W2572710398 @default.
• W3100563362 cites W2590596577 @default.
• W3100563362 cites W2610627565 @default.
• W3100563362 cites W2626431664 @default.
• W3100563362 cites W2725083004 @default.
• W3100563362 cites W2737955012 @default.
• W3100563362 cites W2761593114 @default.
• W3100563362 cites W2778605439 @default.
• W3100563362 cites W2791002606 @default.
• W3100563362 cites W2791314219 @default.
• W3100563362 cites W2792193428 @default.
• W3100563362 cites W2802179259 @default.
• W3100563362 cites W2804029280 @default.
• W3100563362 cites W2805043332 @default.
• W3100563362 cites W2806714098 @default.
• W3100563362 cites W2808882111 @default.
• W3100563362 cites W2811351455 @default.
• W3100563362 cites W2886318654 @default.
• W3100563362 cites W2886681222 @default.
• W3100563362 cites W2889849480 @default.
• W3100563362 cites W2890637781 @default.
• W3100563362 cites W2893023710 @default.
• W3100563362 cites W2897258146 @default.
• W3100563362 cites W2899240074 @default.
• W3100563362 cites W2902723466 @default.
• W3100563362 cites W2913295096 @default.
• W3100563362 cites W2913480382 @default.
• W3100563362 cites W2943053742 @default.
• W3100563362 cites W2945310489 @default.
• W3100563362 cites W2946753897 @default.
• W3100563362 cites W2969331602 @default.
• W3100563362 cites W2977622316 @default.
• W3100563362 cites W2991246746 @default.
• W3100563362 cites W2996717281 @default.
• W3100563362 cites W3003575519 @default.
• W3100563362 cites W3026353017 @default.
• W3100563362 doi "https://doi.org/10.3389/fnbeh.2020.535885" @default.
• W3100563362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7525092" @default.
• W3100563362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33192361" @default.

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