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• W3100571854 abstract "To establish the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic patients scheduled to receive radiation therapy and its impact on management decisions. Between April 2020 and July 2020, patients without influenza-like-illness (ILI) symptoms at four radiation oncology departments (2 academic university hospitals and 2 community hospitals) underwent polymerase chain reaction (PCR) testing for SARS-CoV-2 prior to the initiation of treatment. Three centers were located in New Jersey and one in Southeast Pennsylvania. According to the centers of disease control (CDC), during this period of time, the 7-day average of daily confirmed cases in this region ranged from 3,197 (April 27, 2020) to 295 (July 24, 2020). Testing strategy was determined by each individual institution (all patients vs. chemo-radiotherapy patients only, etc.). Patients were tested either prior to radiotherapy simulation or after simulation but prior to treatment initiation. Patients tested for indications of ILI symptoms were excluded from this analysis. Management of SARS-CoV-2-positive patients was individualized based on disease site and acuity. Over a three-month period, a total of 385 asymptomatic patients were tested either prior to simulation (n=154) or post-simulation, prior to treatment (n=230). A total of 5 patients tested positive for SARS-CoV-2, for a pre-treatment prevalence of 1.3% (2.6% in North/Central NJ and 0.4% in Southern NJ/Southeast PA). The median age of positive patients was 58 years (range: 38-78 years). All positive patients were white and were relatively equally distributed with regard to gender (2 male, 3 female) and ethnicity (2 Hispanic and 3 non-Hispanic). The median Charlson comorbidity score among positive patients was 5. All 5 patients were treated for different primary tumor sites, the large majority had advanced disease (80%), and all were treated for curative intent. The majority of positive patients were being treated with either sequential or concurrent immunosuppressive systemic therapy (80%). Initiation of treatment was delayed for 14 days with the addition of re-testing for 4 patients, while one patient was treated without delay but with additional infectious-disease precautions. In the era of universal respiratory and contact precautions, broad-based pre-treatment asymptomatic testing of radiation oncology patients for SARS-CoV-2 is of limited value, even in a high-incidence region. Future strategies may include focused asymptomatic testing for higher-risk patients according to demographics, comorbidities, disease stage and combination of treatment with cytotoxic chemotherapy." @default.
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• W3100571854 date "2020-12-01" @default.
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• W3100571854 title "A Statewide Multi-institutional Study of Asymptomatic Pre-Treatment Testing of Radiation Therapy Patients for SARS-CoV-2 in a High-Incidence Region of the United States" @default.
• W3100571854 doi "https://doi.org/10.1016/j.ijrobp.2020.09.026" @default.
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