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• W3100598033 abstract "Abstract Heat stress induced by high environmental temperature and humidity affects livestock production and health. With global warming on the uprise, indigenous cattle known for their heat tolerance are gaining importance than the Crossbreds. However, systems biology behind this phenotype in indigenous cattle is less known. This study, revealed novel insights in response to heat stress in Indian cattle (Tharparkar breed – Indigenous breed vs Vrindhavani – Crossbred). The number of DEGs in Crossbred were found to be more, than in Tharparkar, suggesting a greater dysregulation in systems biology in Crossbred. A contrast in gene expression was observed with 18.5 % of upregulated genes in Crossbred (Vrindavani cattle) were downregulated in Tharparkar and 17.5% upregulated genes in Tharparkar were downregulated in Crossbred. The increased HSPs levels have been found positively correlated with tolerance in many species. Upregulation of HSF, HSP70, HSP90, and activation of EIF2 signaling pathway in Tharparkar and vice-versa in Crossbred delineates how Tharparkar, withstands heat stress. Unlike Crossbred, Tharparkar is not only endowed with higher expression of the scavengers (UBE2G1, UBE2S, and UBE2H) of misfolded proteins but also with protectors (VCP, Serp1, and CALK) of naive unfolded proteins. Further, the apoptotic genes that were dysregulated in both genetic groups indicated a relatively higher probability of apoptosis in Crossbred than in Tharparkar. Also, higher expression of the antioxidants in Tharparkar enables it to cope up with higher levels of free radicals generated as a result of heat stress. In this study we found relevant molecules/genes dysregulated in Tharparkar in the direction that can counter heat stress. To best of our knowledge this is a comprehensive comparison between Tharparkar and Crossbred under heat stress using transcriptome analysis." @default.
• W3100598033 created "2020-11-23" @default.
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• W3100598033 date "2020-07-15" @default.
• W3100598033 modified "2023-09-23" @default.
• W3100598033 title "Transcriptome profiling in Indian Cattle revealed novel insights into response to heat stress" @default.
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