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• W3100619583 abstract "Abstract Human PRE-PIK3C2B is a dual nature polycomb response element that interacts with both polycomb as well as trithorax members. In the current study, using 4C-Seq ( C apturing C ircular C hromosomal C onformation- Seq uencing), we identified long-range chromatin interactions associated with PRE-PIK3C2B and validated them with 3C-PCR. We identified both intra-as well as inter-chromosomal interactions, a large proportion of which were found to be closely distributed around transcriptional start sites (TSS). A significant number of interactions were also found to be associated with heterochromatic regions. Meta-analysis of ENCODE ChIP-Seq data identified an overall enrichment of YY1, CTCF as well as histone modification such as H3K4me3 and H3K27me marks in different cell lines. Almost 90% interactions were derived from either intronic or intergenic regions. among which large proportions of intronic interactors were either unique sequences or LINE/SINE derived. In case of intergenic interactions, majority of the interaction were associated with LINE/SINE repeats. We further found that genes proximal to the interactor sequences were co-expressed, they showed reduced expression. To the best of our knowledge this is one of the early demonstrations of long-range interaction of PRE sequences in human genome." @default.
• W3100619583 created "2020-11-23" @default.
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• W3100619583 date "2020-11-11" @default.
• W3100619583 modified "2023-10-14" @default.
• W3100619583 title "HumanPRE-PIK3C2Bexhibits long-range intra- and inter-chromosomal interactions with genomic regions enriched in repressive marks" @default.
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• W3100619583 doi "https://doi.org/10.1101/2020.11.11.378745" @default.
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