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• W3100624079 abstract "Abstract Drosophila melanogaster olfactory neurons have long been thought to express only one chemosensory receptor gene family. There are two main olfactory receptor gene families in Drosophila , the Odorant Receptors (ORs) and the Ionotropic Receptors (IRs). The dozens of odorant binding receptors in each family require at least one co-receptor gene in order to function: Orco for ORs, and Ir25a , Ir8a , and Ir76b for IRs. Using a new genetic knock-in strategy, we targeted the four co-receptors representing the main chemosensory families in Drosophila ( Orco, Ir8a, Ir76b, Ir25a ). Co-receptor knock-in expression patterns were verified as accurate representations of endogenous expression. We find extensive overlap in expression among the different co-receptors. As defined by innervation into antennal lobe glomeruli, Ir25a is broadly expressed in 88% of all olfactory sensory neuron classes and is co-expressed in 82% of Orco+ neuron classes, including all neuron classes in the maxillary palp. Orco , Ir8a , and Ir76b expression patterns are also more expansive than previously assumed. Single sensillum recordings from Orco-expressing Ir25a mutant antennal and palpal neurons identify changes in olfactory responses. These results suggest co-expression of chemosensory receptors is common in olfactory neurons. Together, our data present the first comprehensive map of chemosensory co-receptor expression and reveal their unexpected widespread co-expression in the fly olfactory system." @default.
• W3100624079 created "2020-11-23" @default.
• W3100624079 creator A5016034793 @default.
• W3100624079 creator A5028786045 @default.
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• W3100624079 creator A5062799937 @default.
• W3100624079 creator A5063676027 @default.
• W3100624079 creator A5075361689 @default.
• W3100624079 date "2020-11-08" @default.
• W3100624079 modified "2023-10-13" @default.
• W3100624079 title "Chemoreceptor Co-Expression in <i>Drosophila</i> Olfactory Neurons" @default.
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