FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100642769> ?p ?o ?g. }

• W3100642769 endingPage "3055" @default.
• W3100642769 startingPage "3049" @default.
• W3100642769 abstract "BACKGROUND The main objective of this study was to evaluate the safety and antihypertensive activity of rapeseed peptides and to investigate their potential synergy with captopril. RESULTS The peptides were nontoxic with the maximum tolerated dose exceeding 25 g kg−1 BW d−1 for mice and they had angiotensin converting enzyme (ACE) inhibitory activity with IC50 value of 1.27 mg mL−1. Rapeseed peptides did not have a synergistic effect with captopril on inhibiting ACE activity in simulated digestion tests in vitro. But in vivo they could synergistically augment the amplitude range of lowering blood pressure with captopril by approximately 9% and prolong the antihypertensive effect duration time by over 20% in antihypertension tests of spontaneously hypertensive rats. In addition, the inhibiting effect of rapeseed peptides on ACE activity was noticeable in some rat organs in vivo. Nevertheless, when compared to captopril group, the potential synergy of rapeseed peptides with captopril did not cause a further decrease in ACE activity in the organs but their synergy further improved levels of NO (12.7%) and endothelial nitric oxide synthase (74.1%) in rat serum. Further studies of some peptides identified from rapeseed peptides showed that some of the rapeseed peptides (Cys-Leu, Val-Ala-Pro) could markedly increase contents of NO and endothelial nitric oxide synthase. CONCLUSIONS Rapeseed peptides have antihypertensive activity and they showed potential synergy with captopril in antihypertensive performance in vivo. The synergy was not from ACE inhibition but from other pathways, like improvement in endogenous vasodilator contents. © 2020 Society of Chemical Industry" @default.
• W3100642769 created "2020-11-23" @default.
• W3100642769 creator A5003798686 @default.
• W3100642769 creator A5014908294 @default.
• W3100642769 creator A5029916443 @default.
• W3100642769 creator A5057307061 @default.
• W3100642769 creator A5086503871 @default.
• W3100642769 creator A5090699346 @default.
• W3100642769 date "2020-12-29" @default.
• W3100642769 modified "2023-10-02" @default.
• W3100642769 title "Antihypertensive effect of rapeseed peptides and their potential in improving the effectiveness of captopril" @default.
• W3100642769 cites W1611092567 @default.
• W3100642769 cites W1818503686 @default.
• W3100642769 cites W1971729897 @default.
• W3100642769 cites W1972204925 @default.
• W3100642769 cites W1984446107 @default.
• W3100642769 cites W2007856110 @default.
• W3100642769 cites W2010508362 @default.
• W3100642769 cites W2028637464 @default.
• W3100642769 cites W2043792052 @default.
• W3100642769 cites W2064755337 @default.
• W3100642769 cites W2073975454 @default.
• W3100642769 cites W2075994784 @default.
• W3100642769 cites W2087169338 @default.
• W3100642769 cites W2102086668 @default.
• W3100642769 cites W2140349828 @default.
• W3100642769 cites W2189374332 @default.
• W3100642769 cites W2192291805 @default.
• W3100642769 cites W2195450357 @default.
• W3100642769 cites W2285644154 @default.
• W3100642769 cites W2344741637 @default.
• W3100642769 cites W2434597955 @default.
• W3100642769 cites W2605306153 @default.
• W3100642769 cites W2606140496 @default.
• W3100642769 cites W2621019196 @default.
• W3100642769 cites W2749367413 @default.
• W3100642769 cites W1974156505 @default.
• W3100642769 doi "https://doi.org/10.1002/jsfa.10939" @default.
• W3100642769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33179311" @default.
• W3100642769 hasPublicationYear "2020" @default.
• W3100642769 type Work @default.
• W3100642769 sameAs 3100642769 @default.
• W3100642769 citedByCount "13" @default.
• W3100642769 countsByYear W31006427692021 @default.
• W3100642769 countsByYear W31006427692022 @default.
• W3100642769 countsByYear W31006427692023 @default.
• W3100642769 crossrefType "journal-article" @default.
• W3100642769 hasAuthorship W3100642769A5003798686 @default.
• W3100642769 hasAuthorship W3100642769A5014908294 @default.
• W3100642769 hasAuthorship W3100642769A5029916443 @default.
• W3100642769 hasAuthorship W3100642769A5057307061 @default.
• W3100642769 hasAuthorship W3100642769A5086503871 @default.
• W3100642769 hasAuthorship W3100642769A5090699346 @default.
• W3100642769 hasConcept C126322002 @default.
• W3100642769 hasConcept C150903083 @default.
• W3100642769 hasConcept C178790620 @default.
• W3100642769 hasConcept C181199279 @default.
• W3100642769 hasConcept C185592680 @default.
• W3100642769 hasConcept C207001950 @default.
• W3100642769 hasConcept C27016395 @default.
• W3100642769 hasConcept C2776980637 @default.
• W3100642769 hasConcept C2777622882 @default.
• W3100642769 hasConcept C2779479957 @default.
• W3100642769 hasConcept C2779726014 @default.
• W3100642769 hasConcept C31903555 @default.
• W3100642769 hasConcept C519581460 @default.
• W3100642769 hasConcept C55493867 @default.
• W3100642769 hasConcept C71924100 @default.
• W3100642769 hasConcept C84393581 @default.
• W3100642769 hasConcept C86803240 @default.
• W3100642769 hasConcept C98274493 @default.
• W3100642769 hasConceptScore W3100642769C126322002 @default.
• W3100642769 hasConceptScore W3100642769C150903083 @default.
• W3100642769 hasConceptScore W3100642769C178790620 @default.
• W3100642769 hasConceptScore W3100642769C181199279 @default.
• W3100642769 hasConceptScore W3100642769C185592680 @default.
• W3100642769 hasConceptScore W3100642769C207001950 @default.
• W3100642769 hasConceptScore W3100642769C27016395 @default.
• W3100642769 hasConceptScore W3100642769C2776980637 @default.
• W3100642769 hasConceptScore W3100642769C2777622882 @default.
• W3100642769 hasConceptScore W3100642769C2779479957 @default.
• W3100642769 hasConceptScore W3100642769C2779726014 @default.
• W3100642769 hasConceptScore W3100642769C31903555 @default.
• W3100642769 hasConceptScore W3100642769C519581460 @default.
• W3100642769 hasConceptScore W3100642769C55493867 @default.
• W3100642769 hasConceptScore W3100642769C71924100 @default.
• W3100642769 hasConceptScore W3100642769C84393581 @default.
• W3100642769 hasConceptScore W3100642769C86803240 @default.
• W3100642769 hasConceptScore W3100642769C98274493 @default.
• W3100642769 hasIssue "7" @default.
• W3100642769 hasLocation W31006427691 @default.
• W3100642769 hasOpenAccess W3100642769 @default.
• W3100642769 hasPrimaryLocation W31006427691 @default.
• W3100642769 hasRelatedWork W1985990134 @default.
• W3100642769 hasRelatedWork W1989213644 @default.
• W3100642769 hasRelatedWork W1989680836 @default.
• W3100642769 hasRelatedWork W1997745661 @default.
• W3100642769 hasRelatedWork W2040515822 @default.

• next