Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100644776> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3100644776 endingPage "5196" @default.
- W3100644776 startingPage "5189" @default.
- W3100644776 abstract "Gossypin is known to have antioxidant property and its neuroprotective activity in the ischemia model has been reported. There are no reports on the activity of Gossypin in the learning and memory. The objective of the current work was to evaluate the protective effects of Gossypin in Colchicine-induced Cognitive Dysfunction in rats. For this experiment Male Wistar rats were used and were administered with intracerebroventricular injection of colchicine and oral solution of gossypin (10 or 20 mg/kg) for 3 week to determine the preventive effect of gossypin against colchicine toxicity. Exposure to colchicine produced oxidative stress in rats and model for deficit in memory. The activity of Gossypin in enhancing memory was evaluated using Morris Water Maze for parameters related to spatial memory as Escape latency, island entries, etc. followed by biochemical estimation of AChE enzyme level in the frontal cortex and Hippocampal region of rat brain. Docking interaction study for understanding affinity of Gossypin to AChE enzyme was done using Schrodinger suite. Insilico XP docking study suggested the strong affinity of Gossypin to AChE. Treatment with Gossypin showed significant reduction of the AChE level in frontal cortex but not in Hippocampal region. Gossypin treated group showed slight reduction but not significant in the latency period. However significant increase in the number of island entries was observed. Overall, Gossypin showed significant in silico interaction with AChE, increased AChE activity and slight cognition enhancing property" @default.
- W3100644776 created "2020-11-23" @default.
- W3100644776 creator A5034850797 @default.
- W3100644776 creator A5036331049 @default.
- W3100644776 creator A5040962890 @default.
- W3100644776 creator A5050437476 @default.
- W3100644776 creator A5054933168 @default.
- W3100644776 creator A5068857893 @default.
- W3100644776 creator A5080231514 @default.
- W3100644776 date "2020-11-13" @default.
- W3100644776 modified "2023-09-23" @default.
- W3100644776 title "Protective Effects of Gossypin in Colchicine-induced Cognitive Dysfunction and Oxidative Damage in Rats" @default.
- W3100644776 doi "https://doi.org/10.5958/0974-360x.2020.00907.5" @default.
- W3100644776 hasPublicationYear "2020" @default.
- W3100644776 type Work @default.
- W3100644776 sameAs 3100644776 @default.
- W3100644776 citedByCount "1" @default.
- W3100644776 countsByYear W31006447762022 @default.
- W3100644776 crossrefType "journal-article" @default.
- W3100644776 hasAuthorship W3100644776A5034850797 @default.
- W3100644776 hasAuthorship W3100644776A5036331049 @default.
- W3100644776 hasAuthorship W3100644776A5040962890 @default.
- W3100644776 hasAuthorship W3100644776A5050437476 @default.
- W3100644776 hasAuthorship W3100644776A5054933168 @default.
- W3100644776 hasAuthorship W3100644776A5068857893 @default.
- W3100644776 hasAuthorship W3100644776A5080231514 @default.
- W3100644776 hasConcept C126322002 @default.
- W3100644776 hasConcept C148762608 @default.
- W3100644776 hasConcept C15744967 @default.
- W3100644776 hasConcept C181199279 @default.
- W3100644776 hasConcept C185592680 @default.
- W3100644776 hasConcept C25498285 @default.
- W3100644776 hasConcept C2776151105 @default.
- W3100644776 hasConcept C2776636253 @default.
- W3100644776 hasConcept C2778816929 @default.
- W3100644776 hasConcept C2779059548 @default.
- W3100644776 hasConcept C44752575 @default.
- W3100644776 hasConcept C55493867 @default.
- W3100644776 hasConcept C71924100 @default.
- W3100644776 hasConcept C98274493 @default.
- W3100644776 hasConceptScore W3100644776C126322002 @default.
- W3100644776 hasConceptScore W3100644776C148762608 @default.
- W3100644776 hasConceptScore W3100644776C15744967 @default.
- W3100644776 hasConceptScore W3100644776C181199279 @default.
- W3100644776 hasConceptScore W3100644776C185592680 @default.
- W3100644776 hasConceptScore W3100644776C25498285 @default.
- W3100644776 hasConceptScore W3100644776C2776151105 @default.
- W3100644776 hasConceptScore W3100644776C2776636253 @default.
- W3100644776 hasConceptScore W3100644776C2778816929 @default.
- W3100644776 hasConceptScore W3100644776C2779059548 @default.
- W3100644776 hasConceptScore W3100644776C44752575 @default.
- W3100644776 hasConceptScore W3100644776C55493867 @default.
- W3100644776 hasConceptScore W3100644776C71924100 @default.
- W3100644776 hasConceptScore W3100644776C98274493 @default.
- W3100644776 hasIssue "11" @default.
- W3100644776 hasLocation W31006447761 @default.
- W3100644776 hasOpenAccess W3100644776 @default.
- W3100644776 hasPrimaryLocation W31006447761 @default.
- W3100644776 hasRelatedWork W1987385741 @default.
- W3100644776 hasRelatedWork W2000998536 @default.
- W3100644776 hasRelatedWork W2049340384 @default.
- W3100644776 hasRelatedWork W2079962507 @default.
- W3100644776 hasRelatedWork W2096607844 @default.
- W3100644776 hasRelatedWork W2157726224 @default.
- W3100644776 hasRelatedWork W2187892456 @default.
- W3100644776 hasRelatedWork W2255492998 @default.
- W3100644776 hasRelatedWork W2326049387 @default.
- W3100644776 hasRelatedWork W2376643205 @default.
- W3100644776 hasRelatedWork W2612508760 @default.
- W3100644776 hasRelatedWork W2729845742 @default.
- W3100644776 hasRelatedWork W2742957294 @default.
- W3100644776 hasRelatedWork W2776128910 @default.
- W3100644776 hasRelatedWork W2802116803 @default.
- W3100644776 hasRelatedWork W2895849555 @default.
- W3100644776 hasRelatedWork W2900050804 @default.
- W3100644776 hasRelatedWork W3032827667 @default.
- W3100644776 hasRelatedWork W3083476217 @default.
- W3100644776 hasRelatedWork W3172455432 @default.
- W3100644776 hasVolume "13" @default.
- W3100644776 isParatext "false" @default.
- W3100644776 isRetracted "false" @default.
- W3100644776 magId "3100644776" @default.
- W3100644776 workType "article" @default.