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- W3100649069 abstract "Abstract The dorsomedial striatum (DMS) plays a key role in action selection, but little is known about how direct and indirect pathway spiny projection neurons (dSPNs and iSPNs) contribute to choice suppression in freely moving animals. Here, we used pathway-specific chemogenetic manipulation during a serial choice foraging task to test opposing predictions for iSPN function generated by two theories: 1) the ‘select/suppress’ heuristic which suggests iSPN activity is required to suppress alternate choices and 2) the network-inspired Op ponent A ctor L earning model (OpAL) which proposes that the weighted difference of dSPN and iSPN activity determines choice. We found that chemogenetic activation, but not inhibition, of iSPNs disrupted learned suppression of nonrewarded choices, consistent with the predictions of the OpAL model. Our findings suggest that iSPNs’ role in stopping and freezing does not extend in a simple fashion to choice suppression. These data may provide insights critical for the successful design of interventions for addiction or other conditions in which suppression of behavior is desirable." @default.
- W3100649069 created "2020-11-23" @default.
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- W3100649069 date "2019-06-19" @default.
- W3100649069 modified "2023-09-25" @default.
- W3100649069 title "Choice suppression through opponent but not independent function of the striatal indirect pathway" @default.
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- W3100649069 doi "https://doi.org/10.1101/675850" @default.
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