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• W3100656848 abstract "Abstract Long-lasting confusion and memory difficulties during the postictal state remain a major unmet problem in epilepsy that lacks pathophysiological explanation and treatment. We previously identified that long-lasting periods of severe postictal hypoperfusion/hypoxia, not seizures per se , are associated with memory impairment after temporal lobe seizures. While this observation suggests a key pathophysiological role for insufficient energy delivery, it is unclear how the networks that underlie episodic memory respond to vascular constraints that ultimately give rise to amnesia. Here, we focused on cellular/network level analyses in the CA1 of hippocampus in vivo to determine if neural activity, network oscillations, synaptic transmission, and/or synaptic plasticity are impaired following kindled seizures. Importantly, the induction of severe postictal hypoperfusion/hypoxia was prevented in animals treated by a COX-2 inhibitor, which experimentally separated seizures from their vascular consequences. We observed complete activation of CA1 pyramidal neurons during brief seizures, followed by a short period of reduced activity and flattening of the local field potential that resolved within minutes. During the postictal state, constituting tens of minutes to hours, we observed no changes in neural activity, network oscillations, and synaptic transmission. However, long-term potentiation of the temporoammonic pathway to CA1 was impaired in the postictal period, but only when severe local hypoxia occurred. Lastly, we tested the ability of rats to perform object-context discrimination, which has been proposed to require temporoammonic input to differentiate between sensory experience and the stored representation of the expected object-context pairing. Deficits in this task following seizures were reversed by COX-2 inhibition, which prevented severe postictal hypoxia. These results support a key role for hypoperfusion/hypoxia in postictal memory impairments and identify that many aspects of hippocampal network function are resilient during severe hypoxia except for long-term synaptic plasticity." @default.
• W3100656848 created "2020-11-23" @default.
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• W3100656848 date "2020-01-31" @default.
• W3100656848 modified "2023-10-16" @default.
• W3100656848 title "In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia" @default.
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• W3100656848 cites W1571050529 @default.
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• W3100656848 cites W1897507705 @default.
• W3100656848 cites W1946443775 @default.
• W3100656848 cites W1967258526 @default.
• W3100656848 cites W1969769253 @default.
• W3100656848 cites W1969786011 @default.
• W3100656848 cites W1974719406 @default.
• W3100656848 cites W1975508229 @default.
• W3100656848 cites W1978048708 @default.
• W3100656848 cites W1978939584 @default.
• W3100656848 cites W1990211106 @default.
• W3100656848 cites W1992028186 @default.
• W3100656848 cites W2021297047 @default.
• W3100656848 cites W2021624428 @default.
• W3100656848 cites W2023175942 @default.
• W3100656848 cites W2024032885 @default.
• W3100656848 cites W2024204647 @default.
• W3100656848 cites W2024707130 @default.
• W3100656848 cites W2030769962 @default.
• W3100656848 cites W2033851827 @default.
• W3100656848 cites W2036615793 @default.
• W3100656848 cites W2042422091 @default.
• W3100656848 cites W2063892622 @default.
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• W3100656848 cites W2078385633 @default.
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• W3100656848 cites W2102581541 @default.
• W3100656848 cites W2104583974 @default.
• W3100656848 cites W2105148858 @default.
• W3100656848 cites W2108784183 @default.
• W3100656848 cites W2112575160 @default.
• W3100656848 cites W2114137107 @default.
• W3100656848 cites W2119565218 @default.
• W3100656848 cites W2121007598 @default.
• W3100656848 cites W2125737923 @default.
• W3100656848 cites W2130587723 @default.
• W3100656848 cites W2137572207 @default.
• W3100656848 cites W2146950543 @default.
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• W3100656848 cites W2158993411 @default.
• W3100656848 cites W2163553089 @default.
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• W3100656848 cites W2167917782 @default.
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• W3100656848 cites W2318658284 @default.
• W3100656848 cites W2377750233 @default.
• W3100656848 cites W2395178461 @default.
• W3100656848 cites W2444670246 @default.
• W3100656848 cites W2490261221 @default.
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• W3100656848 cites W2590720381 @default.
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• W3100656848 cites W2753608950 @default.
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• W3100656848 cites W2947504906 @default.
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• W3100656848 doi "https://doi.org/10.1101/2020.01.30.926717" @default.
• W3100656848 hasPublicationYear "2020" @default.
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