FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100658611> ?p ?o ?g. }

• W3100658611 endingPage "102571" @default.
• W3100658611 startingPage "102571" @default.
• W3100658611 abstract "Guillain-Barré syndrome (GBS), including its variant Miller Fisher syndrome (MFS), is an acute peripheral neuropathy that involves autoimmune mechanisms leading to the production of autoantibodies to gangliosides; sialic acid-containing glycosphingolipids. Although association with various genetic polymorphisms in the major histocompatibility complex (MHC) is shown in other autoimmune diseases, GBS is an exception, showing no such link. No significant association was found by genome wide association studies, suggesting that GBS is not associated with common variants. To address the involvement of rare variants in GBS, we analyzed Siglec-10, a sialic acid-recognizing inhibitory receptor expressed on B cells. Here we demonstrate that two rare variants encoding R47Q and A108V substitutions in the ligand-binding domain are significantly accumulated in patients with GBS. Because of strong linkage disequilibrium, there was no patient carrying only one of them. Recombinant Siglec-10 protein containing R47Q but not A108V shows impaired binding to gangliosides. Homology modeling revealed that the R47Q substitution causes marked alteration in the ligand-binding site. Thus, GBS is associated with a rare variant of the SIGLEC10 gene that impairs ligand binding of Siglec-10. Because Siglec-10 regulates antibody production to sialylated antigens, our finding suggests that Siglec-10 regulates development of GBS by suppressing antibody production to gangliosides, with defects in its function predisposing to disease." @default.
• W3100658611 created "2020-11-23" @default.
• W3100658611 creator A5006054960 @default.
• W3100658611 creator A5018467555 @default.
• W3100658611 creator A5023897064 @default.
• W3100658611 creator A5031610276 @default.
• W3100658611 creator A5032016641 @default.
• W3100658611 creator A5035686048 @default.
• W3100658611 creator A5036040469 @default.
• W3100658611 creator A5041914366 @default.
• W3100658611 creator A5052647481 @default.
• W3100658611 creator A5056191820 @default.
• W3100658611 creator A5059782267 @default.
• W3100658611 creator A5073089184 @default.
• W3100658611 creator A5078122217 @default.
• W3100658611 date "2021-01-01" @default.
• W3100658611 modified "2023-10-16" @default.
• W3100658611 title "A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides" @default.
• W3100658611 cites W1581151513 @default.
• W3100658611 cites W1646540353 @default.
• W3100658611 cites W1902589703 @default.
• W3100658611 cites W1971907885 @default.
• W3100658611 cites W1980991473 @default.
• W3100658611 cites W1982288609 @default.
• W3100658611 cites W1993116843 @default.
• W3100658611 cites W1994055510 @default.
• W3100658611 cites W2001337815 @default.
• W3100658611 cites W2029182344 @default.
• W3100658611 cites W2034949980 @default.
• W3100658611 cites W2040213563 @default.
• W3100658611 cites W2045017910 @default.
• W3100658611 cites W2046037953 @default.
• W3100658611 cites W2059614800 @default.
• W3100658611 cites W2064309062 @default.
• W3100658611 cites W2065750747 @default.
• W3100658611 cites W2088104136 @default.
• W3100658611 cites W2102079012 @default.
• W3100658611 cites W2106779017 @default.
• W3100658611 cites W2109097294 @default.
• W3100658611 cites W2110808585 @default.
• W3100658611 cites W2116734756 @default.
• W3100658611 cites W2119301121 @default.
• W3100658611 cites W2120571886 @default.
• W3100658611 cites W2125962985 @default.
• W3100658611 cites W2130790676 @default.
• W3100658611 cites W2143992683 @default.
• W3100658611 cites W2147467901 @default.
• W3100658611 cites W2147751818 @default.
• W3100658611 cites W2154045350 @default.
• W3100658611 cites W2158924104 @default.
• W3100658611 cites W2163550872 @default.
• W3100658611 cites W2167638767 @default.
• W3100658611 cites W2168974130 @default.
• W3100658611 cites W2170487175 @default.
• W3100658611 cites W2335127767 @default.
• W3100658611 cites W2465122791 @default.
• W3100658611 cites W2538447572 @default.
• W3100658611 cites W2601897680 @default.
• W3100658611 cites W2747261161 @default.
• W3100658611 cites W2763578792 @default.
• W3100658611 cites W2886084102 @default.
• W3100658611 cites W2891608559 @default.
• W3100658611 cites W2966214074 @default.
• W3100658611 cites W4211196614 @default.
• W3100658611 cites W4249818277 @default.
• W3100658611 doi "https://doi.org/10.1016/j.jaut.2020.102571" @default.
• W3100658611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33223341" @default.
• W3100658611 hasPublicationYear "2021" @default.
• W3100658611 type Work @default.
• W3100658611 sameAs 3100658611 @default.
• W3100658611 citedByCount "9" @default.
• W3100658611 countsByYear W31006586112021 @default.
• W3100658611 countsByYear W31006586112022 @default.
• W3100658611 countsByYear W31006586112023 @default.
• W3100658611 crossrefType "journal-article" @default.
• W3100658611 hasAuthorship W3100658611A5006054960 @default.
• W3100658611 hasAuthorship W3100658611A5018467555 @default.
• W3100658611 hasAuthorship W3100658611A5023897064 @default.
• W3100658611 hasAuthorship W3100658611A5031610276 @default.
• W3100658611 hasAuthorship W3100658611A5032016641 @default.
• W3100658611 hasAuthorship W3100658611A5035686048 @default.
• W3100658611 hasAuthorship W3100658611A5036040469 @default.
• W3100658611 hasAuthorship W3100658611A5041914366 @default.
• W3100658611 hasAuthorship W3100658611A5052647481 @default.
• W3100658611 hasAuthorship W3100658611A5056191820 @default.
• W3100658611 hasAuthorship W3100658611A5059782267 @default.
• W3100658611 hasAuthorship W3100658611A5073089184 @default.
• W3100658611 hasAuthorship W3100658611A5078122217 @default.
• W3100658611 hasConcept C147483822 @default.
• W3100658611 hasConcept C159654299 @default.
• W3100658611 hasConcept C163764329 @default.
• W3100658611 hasConcept C203014093 @default.
• W3100658611 hasConcept C207936829 @default.
• W3100658611 hasConcept C2778017598 @default.
• W3100658611 hasConcept C2778691916 @default.
• W3100658611 hasConcept C2780115458 @default.
• W3100658611 hasConcept C2780130043 @default.
• W3100658611 hasConcept C54355233 @default.

• next