Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100664189> ?p ?o ?g. }
- W3100664189 abstract "Abstract Mesenchymal stem cells (MSCs) derived from human embryonic stem cells (hESCs) have significant potential for cell-mediated bone regeneration. Our recent study revealed that inhibiting the epigenetic regulator EZH2 plays a key role in promoting the mesodermal differentiation of hESCs. In this study, an epigenome-wide analysis of hESCs and MSCs revealed that growth differentiation factor 6 (GDF6), which is involved in bone formation, was the most upregulated gene associated with MSCs compared to hESCs. Furthermore, we identified GDF6 as a repressive target of EZH2 and found that ectopic GDF6 selectively promoted hESC differentiation towards the mesodermal lineage and enriched the MSC population. Our results provide molecular insights governing the mesenchymal commitment of hESCs and identify an inducing factor that offers strong promise for the future of regenerative medicine." @default.
- W3100664189 created "2020-11-23" @default.
- W3100664189 creator A5019940202 @default.
- W3100664189 creator A5045136242 @default.
- W3100664189 creator A5046819496 @default.
- W3100664189 creator A5078394916 @default.
- W3100664189 date "2020-11-17" @default.
- W3100664189 modified "2023-10-07" @default.
- W3100664189 title "Growth differentiation factor 6, a repressive target of EZH2, promotes the commitment of human embryonic stem cells to mesenchymal stem cells" @default.
- W3100664189 cites W1621302266 @default.
- W3100664189 cites W1823838513 @default.
- W3100664189 cites W1967937835 @default.
- W3100664189 cites W1976454147 @default.
- W3100664189 cites W1980309182 @default.
- W3100664189 cites W1981814533 @default.
- W3100664189 cites W1982756198 @default.
- W3100664189 cites W1988554495 @default.
- W3100664189 cites W1990419270 @default.
- W3100664189 cites W1991164124 @default.
- W3100664189 cites W2015050458 @default.
- W3100664189 cites W2017050785 @default.
- W3100664189 cites W2031688326 @default.
- W3100664189 cites W2036519060 @default.
- W3100664189 cites W2045946031 @default.
- W3100664189 cites W2056089399 @default.
- W3100664189 cites W2073367215 @default.
- W3100664189 cites W2086943348 @default.
- W3100664189 cites W2089426706 @default.
- W3100664189 cites W2090444218 @default.
- W3100664189 cites W2093191361 @default.
- W3100664189 cites W2097220529 @default.
- W3100664189 cites W2104722051 @default.
- W3100664189 cites W2116095696 @default.
- W3100664189 cites W2127835459 @default.
- W3100664189 cites W2128450719 @default.
- W3100664189 cites W2135738344 @default.
- W3100664189 cites W2145769955 @default.
- W3100664189 cites W2153424791 @default.
- W3100664189 cites W2157232603 @default.
- W3100664189 cites W2219461583 @default.
- W3100664189 cites W2241992352 @default.
- W3100664189 cites W2294252084 @default.
- W3100664189 cites W2296433789 @default.
- W3100664189 cites W2560558522 @default.
- W3100664189 cites W2620109538 @default.
- W3100664189 cites W2748688836 @default.
- W3100664189 cites W2886249970 @default.
- W3100664189 cites W3022443218 @default.
- W3100664189 doi "https://doi.org/10.1038/s41413-020-00116-y" @default.
- W3100664189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7672114" @default.
- W3100664189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33298857" @default.
- W3100664189 hasPublicationYear "2020" @default.
- W3100664189 type Work @default.
- W3100664189 sameAs 3100664189 @default.
- W3100664189 citedByCount "5" @default.
- W3100664189 countsByYear W31006641892021 @default.
- W3100664189 countsByYear W31006641892022 @default.
- W3100664189 countsByYear W31006641892023 @default.
- W3100664189 crossrefType "journal-article" @default.
- W3100664189 hasAuthorship W3100664189A5019940202 @default.
- W3100664189 hasAuthorship W3100664189A5045136242 @default.
- W3100664189 hasAuthorship W3100664189A5046819496 @default.
- W3100664189 hasAuthorship W3100664189A5078394916 @default.
- W3100664189 hasBestOaLocation W31006641891 @default.
- W3100664189 hasConcept C104317684 @default.
- W3100664189 hasConcept C10854531 @default.
- W3100664189 hasConcept C117717151 @default.
- W3100664189 hasConcept C145103041 @default.
- W3100664189 hasConcept C148738053 @default.
- W3100664189 hasConcept C150194340 @default.
- W3100664189 hasConcept C190727270 @default.
- W3100664189 hasConcept C198826908 @default.
- W3100664189 hasConcept C28328180 @default.
- W3100664189 hasConcept C54355233 @default.
- W3100664189 hasConcept C86803240 @default.
- W3100664189 hasConcept C95444343 @default.
- W3100664189 hasConceptScore W3100664189C104317684 @default.
- W3100664189 hasConceptScore W3100664189C10854531 @default.
- W3100664189 hasConceptScore W3100664189C117717151 @default.
- W3100664189 hasConceptScore W3100664189C145103041 @default.
- W3100664189 hasConceptScore W3100664189C148738053 @default.
- W3100664189 hasConceptScore W3100664189C150194340 @default.
- W3100664189 hasConceptScore W3100664189C190727270 @default.
- W3100664189 hasConceptScore W3100664189C198826908 @default.
- W3100664189 hasConceptScore W3100664189C28328180 @default.
- W3100664189 hasConceptScore W3100664189C54355233 @default.
- W3100664189 hasConceptScore W3100664189C86803240 @default.
- W3100664189 hasConceptScore W3100664189C95444343 @default.
- W3100664189 hasFunder F4320337365 @default.
- W3100664189 hasIssue "1" @default.
- W3100664189 hasLocation W31006641891 @default.
- W3100664189 hasLocation W31006641892 @default.
- W3100664189 hasLocation W31006641893 @default.
- W3100664189 hasLocation W31006641894 @default.
- W3100664189 hasOpenAccess W3100664189 @default.
- W3100664189 hasPrimaryLocation W31006641891 @default.
- W3100664189 hasRelatedWork W1580484253 @default.
- W3100664189 hasRelatedWork W1973981707 @default.
- W3100664189 hasRelatedWork W1979047014 @default.
- W3100664189 hasRelatedWork W2005970422 @default.