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• W3100667218 endingPage "15240" @default.
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• W3100667218 abstract "We study the nonequilibrium diffusive release of electroneutral molecular cargo encapsulated inside hollow hydrogel nanoparticles. We propose a theoretical model that includes osmotic, steric, and short-range polymer–cargo attractions to determine the effective cargo–hydrogel interaction, ueff*, and the effective diffusion coefficient of the cargo inside the polymer network, Deff*. Using dynamical density functional theory (DDFT), we investigate the scaling of the characteristic release time, τ1/2, with the key parameters involved in the process, namely, ueff*, Deff*, and the swelling ratio. This effort represents a full study of the problem, covering a broad range of cargo sizes and providing predictions for repulsive and attractive polymer shells. Our calculations show that the release time through repulsive polymer networks scales with q2eβueff*/Deff* for βueff* ≫ 1. In this case, the cargo molecules are excluded from the shell of the hydrogel. For attractive shells, the polymer retains the cargo molecules on its internal surface and its interior, and the release time grows exponentially with the attraction strength. The DDFT calculations are compared to an analytical model for the mean first passage time, which provides an excellent quantitative description of the kinetics for both repulsive and attractive shells without fitting parameters. Finally, we apply the method to reproduce experimental results on the release of paclitaxel from hollow poly(4-vinylpyridine) nanoparticles and find that the slow release of the drug can be explained in terms of the strong binding attraction between the drug and the polymer." @default.
• W3100667218 created "2020-11-23" @default.
• W3100667218 creator A5007847165 @default.
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• W3100667218 date "2020-11-11" @default.
• W3100667218 modified "2023-10-18" @default.
• W3100667218 title "Scaling Laws in the Diffusive Release of Neutral Cargo from Hollow Hydrogel Nanoparticles: Paclitaxel-Loaded Poly(4-vinylpyridine)" @default.
• W3100667218 cites W1885856887 @default.
• W3100667218 cites W1964316906 @default.
• W3100667218 cites W1969291323 @default.
• W3100667218 cites W1972103123 @default.
• W3100667218 cites W1972653036 @default.
• W3100667218 cites W1974266608 @default.
• W3100667218 cites W1975974058 @default.
• W3100667218 cites W1976507470 @default.
• W3100667218 cites W1977993705 @default.
• W3100667218 cites W1978807770 @default.
• W3100667218 cites W1982826115 @default.
• W3100667218 cites W1985207344 @default.
• W3100667218 cites W1989026228 @default.
• W3100667218 cites W1997016506 @default.
• W3100667218 cites W1998677002 @default.
• W3100667218 cites W2000910716 @default.
• W3100667218 cites W2002879789 @default.
• W3100667218 cites W2004984389 @default.
• W3100667218 cites W2005512693 @default.
• W3100667218 cites W2007131590 @default.
• W3100667218 cites W2013236964 @default.
• W3100667218 cites W2019924759 @default.
• W3100667218 cites W2027052651 @default.
• W3100667218 cites W2027992078 @default.
• W3100667218 cites W2029375419 @default.
• W3100667218 cites W2031341472 @default.
• W3100667218 cites W2032445169 @default.
• W3100667218 cites W2033586074 @default.
• W3100667218 cites W2034715370 @default.
• W3100667218 cites W2035946649 @default.
• W3100667218 cites W2037065466 @default.
• W3100667218 cites W2037477418 @default.
• W3100667218 cites W2047632869 @default.
• W3100667218 cites W2051849281 @default.
• W3100667218 cites W2056331631 @default.
• W3100667218 cites W2059890285 @default.
• W3100667218 cites W2069480183 @default.
• W3100667218 cites W2071423096 @default.
• W3100667218 cites W2075524179 @default.
• W3100667218 cites W2080033998 @default.
• W3100667218 cites W2085266415 @default.
• W3100667218 cites W2102917770 @default.
• W3100667218 cites W2113097031 @default.
• W3100667218 cites W2120216807 @default.
• W3100667218 cites W2130876997 @default.
• W3100667218 cites W2141947008 @default.
• W3100667218 cites W2154747925 @default.
• W3100667218 cites W2156851029 @default.
• W3100667218 cites W2159715125 @default.
• W3100667218 cites W2169222922 @default.
• W3100667218 cites W2171753421 @default.
• W3100667218 cites W2211773131 @default.
• W3100667218 cites W2293541728 @default.
• W3100667218 cites W2301645860 @default.
• W3100667218 cites W2307975193 @default.
• W3100667218 cites W2318269081 @default.
• W3100667218 cites W2322256054 @default.
• W3100667218 cites W2329054428 @default.
• W3100667218 cites W2514292708 @default.
• W3100667218 cites W2516756052 @default.
• W3100667218 cites W2535849056 @default.
• W3100667218 cites W2539107597 @default.
• W3100667218 cites W2552739997 @default.
• W3100667218 cites W2572285342 @default.
• W3100667218 cites W2578325125 @default.
• W3100667218 cites W2583398989 @default.
• W3100667218 cites W2607232751 @default.
• W3100667218 cites W2612841386 @default.
• W3100667218 cites W2625597098 @default.
• W3100667218 cites W2725567706 @default.
• W3100667218 cites W2779219965 @default.
• W3100667218 cites W2781704662 @default.
• W3100667218 cites W2892053878 @default.
• W3100667218 cites W2894675488 @default.
• W3100667218 cites W2906282704 @default.
• W3100667218 cites W2909752677 @default.
• W3100667218 cites W2986480275 @default.
• W3100667218 cites W2996451596 @default.
• W3100667218 cites W3005857758 @default.
• W3100667218 cites W3011968353 @default.
• W3100667218 cites W3021053144 @default.
• W3100667218 cites W3042582896 @default.
• W3100667218 cites W3098166199 @default.

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