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- W3100681947 startingPage "200011" @default.
- W3100681947 abstract "Cystic fibrosis (CF) lung disease is characterised by mucus stasis, chronic infection and inflammation, causing progressive structural lung disease and eventual respiratory failure. CF airways are inhabited by an ecologically diverse polymicrobial environment with vast potential for interspecies interactions, which may be a contributing factor to disease progression. Pseudomonas aeruginosa and Aspergillus fumigatus are the most common bacterial and fungal species present in CF airways respectively and coinfection results in a worse disease phenotype.In this review we examine existing expert knowledge of chronic co-infection with P. aeruginosa and A. fumigatus in CF patients. We summarise the mechanisms of interaction and evaluate the clinical and inflammatory impacts of this co-infection.P. aeruginosa inhibits A. fumigatus through multiple mechanisms: phenazine secretion, iron competition, quorum sensing and through diffusible small molecules. A. fumigatus reciprocates inhibition through gliotoxin release and phenotypic adaptations enabling evasion of P. aeruginosa inhibition. Volatile organic compounds secreted by P. aeruginosa stimulate A. fumigatus growth, while A. fumigatus stimulates P. aeruginosa production of cytotoxic elastase.A complex bi-directional relationship exists between P. aeruginosa and A. fumigatus, exhibiting both mutually antagonistic and cooperative facets. Cross-sectional data indicate a worsened disease state in coinfected patients; however, robust longitudinal studies are required to derive causality and to determine whether interspecies interaction contributes to disease progression." @default.
- W3100681947 created "2020-11-23" @default.
- W3100681947 creator A5005502852 @default.
- W3100681947 creator A5033892561 @default.
- W3100681947 creator A5048945685 @default.
- W3100681947 creator A5049298196 @default.
- W3100681947 creator A5089767337 @default.
- W3100681947 date "2020-11-18" @default.
- W3100681947 modified "2023-10-10" @default.
- W3100681947 title "Coinfection with <i>Pseudomonas aeruginosa</i> and <i>Aspergillus fumigatus</i> in cystic fibrosis" @default.
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