FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100682961> ?p ?o ?g. }

• W3100682961 abstract "Abstract The cell division rate, size, and gene expression programmes change in response to external conditions. These global changes impact on average concentrations of biomolecule and their variability or noise. Gene expression is inherently stochastic, and noise levels of individual proteins depend on synthesis and degradation rates as well as on cell-cycle dynamics. We have modelled stochastic gene expression inside growing and dividing cells to study the effect of division rates on noise in mRNA and protein expression. We use assumptions and parameters relevant to Escherichia coli , for which abundant quantitative data are available. We find that coupling of transcription, but not translation rates to the rate of cell division can result in protein concentration and noise homeostasis across conditions. Interestingly, we find that the increased cell size at fast division rates, observed in E. coli d other unicellular organisms, buffers noise levels even for proteins with decreased expression at faster growth. We then investigate the functional importance of these regulations using gene regulatory networks that exhibit bi-stability and oscillations. We find that network topology affects robustness to changes in division rate in complex and unexpected ways. In particular, a simple model of persistence, based on global physiological feedback, predicts increased proportion of persistors cells at slow division rates. Altogether, our study reveals how cell size regulation in response to cell division rate could help controlling gene expression noise. It also highlights that understanding of circuits’ robustness across growth conditions is key for the effective design of synthetic biological systems." @default.
• W3100682961 created "2020-11-23" @default.
• W3100682961 creator A5016598665 @default.
• W3100682961 creator A5052845258 @default.
• W3100682961 creator A5066647656 @default.
• W3100682961 date "2017-10-26" @default.
• W3100682961 modified "2023-10-17" @default.
• W3100682961 title "Division rate, cell size and proteome allocation: impact on gene expression noise and implications for the dynamics of genetic circuits" @default.
• W3100682961 cites W1966062610 @default.
• W3100682961 cites W1966645118 @default.
• W3100682961 cites W1966829410 @default.
• W3100682961 cites W1982396530 @default.
• W3100682961 cites W1985161570 @default.
• W3100682961 cites W1985229551 @default.
• W3100682961 cites W1990926390 @default.
• W3100682961 cites W1991746217 @default.
• W3100682961 cites W1996666978 @default.
• W3100682961 cites W2014150977 @default.
• W3100682961 cites W2014512134 @default.
• W3100682961 cites W2034738976 @default.
• W3100682961 cites W2036449301 @default.
• W3100682961 cites W2044079597 @default.
• W3100682961 cites W2047453261 @default.
• W3100682961 cites W2053460598 @default.
• W3100682961 cites W2061659241 @default.
• W3100682961 cites W2066720146 @default.
• W3100682961 cites W2068978083 @default.
• W3100682961 cites W2078097311 @default.
• W3100682961 cites W2085020901 @default.
• W3100682961 cites W2087324035 @default.
• W3100682961 cites W2090232842 @default.
• W3100682961 cites W2090433162 @default.
• W3100682961 cites W2096705138 @default.
• W3100682961 cites W2101762601 @default.
• W3100682961 cites W2104187897 @default.
• W3100682961 cites W2106895423 @default.
• W3100682961 cites W2107275175 @default.
• W3100682961 cites W2108493072 @default.
• W3100682961 cites W2111354165 @default.
• W3100682961 cites W2114458220 @default.
• W3100682961 cites W2115606218 @default.
• W3100682961 cites W2123425265 @default.
• W3100682961 cites W2123999282 @default.
• W3100682961 cites W2127878017 @default.
• W3100682961 cites W2130665506 @default.
• W3100682961 cites W2134440848 @default.
• W3100682961 cites W2134759932 @default.
• W3100682961 cites W2135783707 @default.
• W3100682961 cites W2137088684 @default.
• W3100682961 cites W2151019321 @default.
• W3100682961 cites W2152223517 @default.
• W3100682961 cites W2165511425 @default.
• W3100682961 cites W2165948144 @default.
• W3100682961 cites W2166366044 @default.
• W3100682961 cites W2167244112 @default.
• W3100682961 cites W2170018565 @default.
• W3100682961 cites W2171280873 @default.
• W3100682961 cites W2172213445 @default.
• W3100682961 cites W2177384541 @default.
• W3100682961 cites W2187281001 @default.
• W3100682961 cites W2191571534 @default.
• W3100682961 cites W2196842638 @default.
• W3100682961 cites W2215246329 @default.
• W3100682961 cites W2272794876 @default.
• W3100682961 cites W2402625173 @default.
• W3100682961 cites W2416065856 @default.
• W3100682961 cites W2485910554 @default.
• W3100682961 cites W2517303441 @default.
• W3100682961 cites W2563408447 @default.
• W3100682961 cites W2605452982 @default.
• W3100682961 cites W2622305133 @default.
• W3100682961 cites W2730330710 @default.
• W3100682961 cites W2736127215 @default.
• W3100682961 cites W2736791128 @default.
• W3100682961 cites W2748521462 @default.
• W3100682961 cites W2766359776 @default.
• W3100682961 cites W2769086206 @default.
• W3100682961 cites W4293021319 @default.
• W3100682961 cites W560388810 @default.
• W3100682961 doi "https://doi.org/10.1101/209593" @default.
• W3100682961 hasPublicationYear "2017" @default.
• W3100682961 type Work @default.
• W3100682961 sameAs 3100682961 @default.
• W3100682961 citedByCount "0" @default.
• W3100682961 crossrefType "posted-content" @default.
• W3100682961 hasAuthorship W3100682961A5016598665 @default.
• W3100682961 hasAuthorship W3100682961A5052845258 @default.
• W3100682961 hasAuthorship W3100682961A5066647656 @default.
• W3100682961 hasBestOaLocation W31006829611 @default.
• W3100682961 hasConcept C104317684 @default.
• W3100682961 hasConcept C138885662 @default.
• W3100682961 hasConcept C1491633281 @default.
• W3100682961 hasConcept C150194340 @default.
• W3100682961 hasConcept C152662350 @default.
• W3100682961 hasConcept C165864922 @default.
• W3100682961 hasConcept C179926584 @default.
• W3100682961 hasConcept C186060115 @default.
• W3100682961 hasConcept C191908910 @default.
• W3100682961 hasConcept C29537977 @default.
• W3100682961 hasConcept C41895202 @default.

• next