Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100687915> ?p ?o ?g. }
- W3100687915 abstract "Weight gain and obesity are global health concerns contributing to morbidity with increased risks of cardiovascular disease, diabetes, liver steatohepatitis and cancer. Pharmacological therapies or bariatric surgery are often required for those who fail to adhere to diet and lifestyle modifications. Metformin, a widely used antidiabetic agent, seems to have a health benefit beyond its anti-hyperglycemic properties, with few side effects. Emerging evidence shows weight loss to be associated with metformin in both diabetic and non-diabetic individuals. Recently, the growth differentiation factor 15 (GDF-15), a member of the transforming growth factor beta superfamily, has been identified as a key mediator of metformin-induced weight loss. Metformin increases the secretion of GDF-15, which binds exclusively to glial cell-derived neurotrophic factor family receptor alpha-like (GFRAL). This gut-brain cytokine works as a prominent player in reducing food intake and body weight in health and disease, like anorexia nervosa and cancer. Herein, we critically review advances in the understanding of the weight-reducing effects of metformin via the GDF-15 pathway." @default.
- W3100687915 created "2020-11-23" @default.
- W3100687915 creator A5011756139 @default.
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- W3100687915 creator A5061151592 @default.
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- W3100687915 creator A5068034539 @default.
- W3100687915 date "2020-11-18" @default.
- W3100687915 modified "2023-10-13" @default.
- W3100687915 title "GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin" @default.
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