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• W3100688369 endingPage "3259" @default.
• W3100688369 startingPage "3247" @default.
• W3100688369 abstract "Bacterial cell surface glycans are quintessential drug targets due to their critical role in colonization of the host, pathogen survival, and immune evasion. The dense cell envelope glycocalyx contains distinctive monosaccharides that are stitched together into higher order glycans to yield exclusively bacterial structures that are critical for strain fitness and pathogenesis. However, the systematic study and inhibition of bacterial glycosylation enzymes remains challenging. Bacteria produce glycans containing rare sugars refractory to traditional glycan analysis, complicating the study of bacterial glycans and the identification of their biosynthesis machinery. To ease the study of bacterial glycans in the absence of detailed structural information, we used metabolic glycan labeling to detect changes in glycan biosynthesis. Here, we screened wild-type versus mutant strains of the gastric pathogen Helicobacter pylori, ultimately permitting the identification of genes involved in glycoprotein and lipopolysaccharide biosynthesis. Our findings provide the first evidence that H. pylori protein glycosylation proceeds via a lipid carrier-mediated pathway that overlaps with lipopolysaccharide biosynthesis. Protein glycosylation mutants displayed fitness defects consistent with those induced by small molecule glycosylation inhibitors. Broadly, our results suggest a facile approach to screen for bacterial glycosylation genes and gain insight into their biosynthesis and functional importance, even in the absence of glycan structural information." @default.
• W3100688369 created "2020-11-23" @default.
• W3100688369 creator A5000058361 @default.
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• W3100688369 date "2020-11-13" @default.
• W3100688369 modified "2023-10-15" @default.
• W3100688369 title "Metabolic Glycan Labeling-Based Screen to Identify Bacterial Glycosylation Genes" @default.
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• W3100688369 doi "https://doi.org/10.1021/acsinfecdis.0c00612" @default.
• W3100688369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7808405" @default.
• W3100688369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33186014" @default.
• W3100688369 hasPublicationYear "2020" @default.
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