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- W3100691810 abstract "Over the last few decades, hot-melt extrusion (HME) has emerged as one of the most versatile technologies to develop polymeric solid dispersions. The overarching pharmaceutical applications of this technology has marked a significant impact mainly in the area of dissolution enhancement of poorly water-soluble drugs, taste masking of bitter active pharmaceutical ingredients (APIs), sustained and controlled release drug delivery, solid-state cocrystals, oral films, and most recently continuous manufacturing by embracing quality by design and process analytical technology. HME has now displayed a holistic significance by introducing its potential to couple with modern technology such as three-dimensional (3D) printing for personalized applications too. The advantage of coupling HME with a 3D printing technique has resulted in many publications and application notes recently. The process technology, advantages, formulation consideration and critical attributes, and wide-ranging pharmaceutical applications of HME will be critically surveyed in this chapter." @default.
- W3100691810 created "2020-11-23" @default.
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- W3100691810 date "2021-01-01" @default.
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- W3100691810 title "Hot-melt extrusion: a versatile technology" @default.
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- W3100691810 doi "https://doi.org/10.1016/b978-0-12-820007-0.00033-7" @default.
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