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• W3100698156 abstract "Spontaneous abortion (SA) is the most frequently occurring pregnancy disorder and is a serious threat to women's health. Identifying novel risk factors and the molecular mechanisms underlying SA are important. The present study reported that the RNA expression levels of long non‑coding RNA H19 were lower in SA group compared with those in the control group, and the expression of <em>Bax</em> was increased and levels of <em>Bcl‑2</em> and phospholipid hydroperoxide glutathione peroxidase (<em>GPX4</em>) were decreased in SA group at both the mRNA and protein levels. H19 expression was positively correlated with <em>Bcl‑2</em> and <em>GPX4</em> expression and negatively linked with <em>Bax</em> levels. It was demonstrated that silencing H19 downregulated <em>Bcl‑2</em> and <em>GPX4</em> expression and upregulated <em>Bax</em> expression at both the mRNA and protein levels in HTR‑8/SVneo trophoblast cells. In conclusion, the present findings suggested that H19 has important roles in SA by promoting apoptosis and ferroptosis." @default.
• W3100698156 created "2020-11-23" @default.
• W3100698156 creator A5008339483 @default.
• W3100698156 creator A5031515657 @default.
• W3100698156 date "2020-11-17" @default.
• W3100698156 modified "2023-10-17" @default.
• W3100698156 title "Long non‑coding RNA H19 regulates Bcl‑2, Bax and phospholipid hydroperoxide glutathione peroxidase expression in spontaneous abortion" @default.
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• W3100698156 doi "https://doi.org/10.3892/etm.2020.9473" @default.
• W3100698156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7706391" @default.
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