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- W3100731418 abstract "Abstract GABAergic interneurons are proposed to be critical for early activity and synapse formation by directly exciting, rather than inhibiting, neurons in developing hippocampus and neocortex. However, the role of GABAergic neurons in the generation of neonatal network activity has not been tested in vivo , and recent studies have challenged the excitatory nature of early GABA. By locally manipulating interneuron activity in unanesthetized neonatal mice, we show that GABAergic neurons are indeed excitatory in hippocampus at postnatal-day 3 (P3), and responsible for most of the spontaneous firing of pyramidal cells at that age. Hippocampal interneurons become inhibitory by P7, whereas cortical interneurons are inhibitory at P3 and remain so throughout development. This regional and age heterogeneity is the result of a change in chloride reversal potential as activation of light-gated anion channels expressed in glutamatergic neurons causes firing in hippocampus at P3, but silences it at P7. This study in the intact brain reveals a critical role for GABAergic interneuron excitation in neonatal hippocampus, and a surprising heterogeneity of interneuron function in cortical circuits that was not predicted from in vitro studies." @default.
- W3100731418 created "2020-11-23" @default.
- W3100731418 creator A5037321020 @default.
- W3100731418 date "2019-07-13" @default.
- W3100731418 modified "2023-09-26" @default.
- W3100731418 title "Regional heterogeneity of developing GABAergic interneuron excitation in vivo" @default.
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- W3100731418 doi "https://doi.org/10.1101/701862" @default.
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