FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100732454> ?p ?o ?g. }

• W3100732454 endingPage "1170" @default.
• W3100732454 startingPage "1163" @default.
• W3100732454 abstract "Colon cancer is the third most common cancer worldwide. Many miRNAs have been reported to be involved in colon cancer progression. However, there are only a few studies on the role of miR-219a-1 in colon cancer, and the molecular mechanisms involved remain unclear. The aim of this study was to investigate the miR-219a-1 level in patients with colon cancer and to explore both the effects and regulatory mechanisms of miR-219a-1 in the malignancy of colon cancer cells. Real-time PCR and western blot analysis were used to analyze the expression levels of miR-219a-1 and mediator of ErbB2-driven cell motility 1. Cell Counting Kit-8, transwell and wound-healing assays were performed to investigate the malignant ability of colon cancer cells. A luciferase assay was performed to explore whether miR-219a-1 could directly bind to 3'-UTR region of MEMO1. miR-219a-1 was found to be downregulated in colon cancer cell lines and in patients with colon cancer. Additionally, miR-219a-1 could inhibit colon cancer cell proliferation, invasion and migration. We identified MEMO1 as a novel potential target gene of miR-219a-1. Luciferase assays showed that miR-219a-1 could directly bind to 3'-UTR of MEMO1. Overexpression of miR-219a-1 in colon cancer cells could inhibit the expression of MEMO1. Furthermore, MEMO1 was upregulated in patients with colon cancer, which was inversely correlated with miR-219a-1 levels. In conclusion, our study revealed that miR-219a-1 exerts anti-tumor effects and regulates colon cancer cell proliferation, invasion and migration by targeting MEMO1, suggesting that miR-219a-1 could act as a therapeutic target in colon cancer." @default.
• W3100732454 created "2020-11-23" @default.
• W3100732454 creator A5001275689 @default.
• W3100732454 creator A5032796228 @default.
• W3100732454 creator A5040747953 @default.
• W3100732454 creator A5045477206 @default.
• W3100732454 creator A5050332734 @default.
• W3100732454 creator A5051607146 @default.
• W3100732454 date "2020-11-20" @default.
• W3100732454 modified "2023-09-30" @default.
• W3100732454 title "miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting <i>MEMO1</i>" @default.
• W3100732454 cites W1977558544 @default.
• W3100732454 cites W2008803162 @default.
• W3100732454 cites W2013058114 @default.
• W3100732454 cites W2035707605 @default.
• W3100732454 cites W2047101312 @default.
• W3100732454 cites W2089771126 @default.
• W3100732454 cites W2092696994 @default.
• W3100732454 cites W2117321105 @default.
• W3100732454 cites W2123203364 @default.
• W3100732454 cites W2129355962 @default.
• W3100732454 cites W2133968430 @default.
• W3100732454 cites W2150625137 @default.
• W3100732454 cites W2152024378 @default.
• W3100732454 cites W2418147871 @default.
• W3100732454 cites W2563147249 @default.
• W3100732454 cites W2568468602 @default.
• W3100732454 cites W2580890017 @default.
• W3100732454 cites W2592982749 @default.
• W3100732454 cites W2743929105 @default.
• W3100732454 cites W2753042008 @default.
• W3100732454 cites W2765678294 @default.
• W3100732454 cites W2781525129 @default.
• W3100732454 cites W2803323338 @default.
• W3100732454 cites W2900454916 @default.
• W3100732454 cites W2916215984 @default.
• W3100732454 cites W2942725870 @default.
• W3100732454 cites W4237654651 @default.
• W3100732454 doi "https://doi.org/10.1080/15384047.2020.1843897" @default.
• W3100732454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7722797" @default.
• W3100732454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33218285" @default.
• W3100732454 hasPublicationYear "2020" @default.
• W3100732454 type Work @default.
• W3100732454 sameAs 3100732454 @default.
• W3100732454 citedByCount "10" @default.
• W3100732454 countsByYear W31007324542021 @default.
• W3100732454 countsByYear W31007324542022 @default.
• W3100732454 countsByYear W31007324542023 @default.
• W3100732454 crossrefType "journal-article" @default.
• W3100732454 hasAuthorship W3100732454A5001275689 @default.
• W3100732454 hasAuthorship W3100732454A5032796228 @default.
• W3100732454 hasAuthorship W3100732454A5040747953 @default.
• W3100732454 hasAuthorship W3100732454A5045477206 @default.
• W3100732454 hasAuthorship W3100732454A5050332734 @default.
• W3100732454 hasAuthorship W3100732454A5051607146 @default.
• W3100732454 hasBestOaLocation W31007324541 @default.
• W3100732454 hasConcept C104317684 @default.
• W3100732454 hasConcept C111335760 @default.
• W3100732454 hasConcept C121608353 @default.
• W3100732454 hasConcept C126322002 @default.
• W3100732454 hasConcept C127561419 @default.
• W3100732454 hasConcept C142724271 @default.
• W3100732454 hasConcept C145059251 @default.
• W3100732454 hasConcept C2776415932 @default.
• W3100732454 hasConcept C2779399171 @default.
• W3100732454 hasConcept C502942594 @default.
• W3100732454 hasConcept C526805850 @default.
• W3100732454 hasConcept C54009773 @default.
• W3100732454 hasConcept C54355233 @default.
• W3100732454 hasConcept C62112901 @default.
• W3100732454 hasConcept C71924100 @default.
• W3100732454 hasConcept C81885089 @default.
• W3100732454 hasConcept C86803240 @default.
• W3100732454 hasConcept C96232424 @default.
• W3100732454 hasConceptScore W3100732454C104317684 @default.
• W3100732454 hasConceptScore W3100732454C111335760 @default.
• W3100732454 hasConceptScore W3100732454C121608353 @default.
• W3100732454 hasConceptScore W3100732454C126322002 @default.
• W3100732454 hasConceptScore W3100732454C127561419 @default.
• W3100732454 hasConceptScore W3100732454C142724271 @default.
• W3100732454 hasConceptScore W3100732454C145059251 @default.
• W3100732454 hasConceptScore W3100732454C2776415932 @default.
• W3100732454 hasConceptScore W3100732454C2779399171 @default.
• W3100732454 hasConceptScore W3100732454C502942594 @default.
• W3100732454 hasConceptScore W3100732454C526805850 @default.
• W3100732454 hasConceptScore W3100732454C54009773 @default.
• W3100732454 hasConceptScore W3100732454C54355233 @default.
• W3100732454 hasConceptScore W3100732454C62112901 @default.
• W3100732454 hasConceptScore W3100732454C71924100 @default.
• W3100732454 hasConceptScore W3100732454C81885089 @default.
• W3100732454 hasConceptScore W3100732454C86803240 @default.
• W3100732454 hasConceptScore W3100732454C96232424 @default.
• W3100732454 hasFunder F4320321001 @default.
• W3100732454 hasIssue "12" @default.
• W3100732454 hasLocation W31007324541 @default.
• W3100732454 hasLocation W31007324542 @default.
• W3100732454 hasLocation W31007324543 @default.
• W3100732454 hasOpenAccess W3100732454 @default.

• next