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• W3100754674 abstract "Childhood obesity is escalating globally. Lifestyle and behavioral changes, which are the frequently used interventions in clinical practice, lead to only modest improvements in children with established obesity. Bariatric surgery is currently the most effective obesity treatment but has very limited utilization in pediatric obesity and is preferentially used for children with worsening comorbidities. There exists a massive treatment gap for children suffering with obesity especially after the failure of lifestyle modifications. Pharmacotherapy that is an established management tool in adults is very infrequently used in children. Only two medications, Phentermine and Orlistat are approved by the Food and Drug Administration (FDA) for use in adolescent obesity. Herein, we discuss the current landscape and available literature on the use of antiobesity pharmacotherapy in children.There are emerging pediatric data about the efficacy of the many weight loss medications that are FDA approved in adults. Moreover, more clinical trials are underway on the rarer, intractable forms of obesity such as monogenic, syndromic, and hypothalamic obesity.Weight loss medications in children, like adults, have variable efficacy and similar side effect profiles. Rigorous research and improved education of providers about weight loss medications may address the huge treatment gap in severe pediatric obesity." @default.
• W3100754674 created "2020-11-23" @default.
• W3100754674 creator A5010037150 @default.
• W3100754674 creator A5015845203 @default.
• W3100754674 creator A5069805093 @default.
• W3100754674 date "2020-11-12" @default.
• W3100754674 modified "2023-09-30" @default.
• W3100754674 title "Pharmacotherapy in pediatric obesity: current evidence and landscape" @default.
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• W3100754674 doi "https://doi.org/10.1097/med.0000000000000587" @default.
• W3100754674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8082722" @default.
• W3100754674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33186194" @default.
• W3100754674 hasPublicationYear "2020" @default.
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