Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100760010> ?p ?o ?g. }
- W3100760010 abstract "The spike glycoprotein of the SARS-CoV-2 virus, which causes COVID-19, has attracted attention for its vaccine potential and binding capacity to host cell surface receptors. Much of this research focus has centered on the ectodomain of the spike protein. The ectodomain is anchored to a transmembrane region, followed by a cytoplasmic tail. Here we report a distant sequence similarity between the cysteine-rich cytoplasmic tail of the coronavirus spike protein and the hepcidin protein that is found in humans and other vertebrates. Hepcidin is thought to be the key regulator of iron metabolism in humans. An implication of this preliminary observation is to suggest a potential route of investigation in the coronavirus research field making use of an already-established literature on the interplay of local and systemic iron regulation, cytokine-mediated inflammatory processes, respiratory infections and the hepcidin protein. The question of possible homology and an evolutionary connection between the viral spike protein and hepcidin is not assessed in this report, but some scenarios for its study are discussed." @default.
- W3100760010 created "2020-11-23" @default.
- W3100760010 creator A5000354092 @default.
- W3100760010 date "2020-10-16" @default.
- W3100760010 modified "2023-10-06" @default.
- W3100760010 title "COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein" @default.
- W3100760010 cites W1141274631 @default.
- W3100760010 cites W1576551594 @default.
- W3100760010 cites W1761222131 @default.
- W3100760010 cites W1763745741 @default.
- W3100760010 cites W1971894038 @default.
- W3100760010 cites W1972540879 @default.
- W3100760010 cites W1978774658 @default.
- W3100760010 cites W1984598477 @default.
- W3100760010 cites W1988439811 @default.
- W3100760010 cites W1993704013 @default.
- W3100760010 cites W2004373421 @default.
- W3100760010 cites W2009878128 @default.
- W3100760010 cites W2011262372 @default.
- W3100760010 cites W2012505332 @default.
- W3100760010 cites W2021010261 @default.
- W3100760010 cites W2025063713 @default.
- W3100760010 cites W2025200316 @default.
- W3100760010 cites W2027624389 @default.
- W3100760010 cites W2032378111 @default.
- W3100760010 cites W2034512365 @default.
- W3100760010 cites W2038230871 @default.
- W3100760010 cites W2049741486 @default.
- W3100760010 cites W2054421541 @default.
- W3100760010 cites W2067531222 @default.
- W3100760010 cites W2071569701 @default.
- W3100760010 cites W2073271820 @default.
- W3100760010 cites W2074040887 @default.
- W3100760010 cites W2086046427 @default.
- W3100760010 cites W2087420232 @default.
- W3100760010 cites W2092095100 @default.
- W3100760010 cites W2093392569 @default.
- W3100760010 cites W2097188280 @default.
- W3100760010 cites W2108843246 @default.
- W3100760010 cites W2111495112 @default.
- W3100760010 cites W2114085390 @default.
- W3100760010 cites W2122315165 @default.
- W3100760010 cites W2130055651 @default.
- W3100760010 cites W2130382251 @default.
- W3100760010 cites W2134747025 @default.
- W3100760010 cites W2136719235 @default.
- W3100760010 cites W2137268987 @default.
- W3100760010 cites W2141885858 @default.
- W3100760010 cites W2146444665 @default.
- W3100760010 cites W2158656095 @default.
- W3100760010 cites W2161386023 @default.
- W3100760010 cites W2161998284 @default.
- W3100760010 cites W2337435435 @default.
- W3100760010 cites W2401696679 @default.
- W3100760010 cites W2468280881 @default.
- W3100760010 cites W2513547424 @default.
- W3100760010 cites W2580449060 @default.
- W3100760010 cites W2584260978 @default.
- W3100760010 cites W2609745626 @default.
- W3100760010 cites W2614345566 @default.
- W3100760010 cites W2765468809 @default.
- W3100760010 cites W2774178591 @default.
- W3100760010 cites W2775736985 @default.
- W3100760010 cites W2778704175 @default.
- W3100760010 cites W2785884406 @default.
- W3100760010 cites W2793802684 @default.
- W3100760010 cites W2886087099 @default.
- W3100760010 cites W2888487980 @default.
- W3100760010 cites W2912436263 @default.
- W3100760010 cites W2917865008 @default.
- W3100760010 cites W2946842271 @default.
- W3100760010 cites W2947642275 @default.
- W3100760010 cites W2963530933 @default.
- W3100760010 cites W2968088907 @default.
- W3100760010 cites W2971983526 @default.
- W3100760010 cites W2972647850 @default.
- W3100760010 cites W2973305257 @default.
- W3100760010 cites W2974771668 @default.
- W3100760010 cites W2977026040 @default.
- W3100760010 cites W2992538743 @default.
- W3100760010 cites W2993780472 @default.
- W3100760010 cites W3002108456 @default.
- W3100760010 cites W3003217347 @default.
- W3100760010 cites W3004896487 @default.
- W3100760010 cites W3005409321 @default.
- W3100760010 cites W3005477973 @default.
- W3100760010 cites W3006116465 @default.
- W3100760010 cites W3006252254 @default.
- W3100760010 cites W3007643904 @default.
- W3100760010 cites W3008443627 @default.
- W3100760010 cites W3008990592 @default.
- W3100760010 cites W3009106280 @default.
- W3100760010 cites W3009335299 @default.
- W3100760010 cites W3009849619 @default.
- W3100760010 cites W3009885589 @default.
- W3100760010 cites W3011127849 @default.
- W3100760010 cites W3012421327 @default.
- W3100760010 cites W3012696170 @default.
- W3100760010 cites W3013176450 @default.
- W3100760010 cites W3013186573 @default.