FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100773375> ?p ?o ?g. }

• W3100773375 endingPage "2666" @default.
• W3100773375 startingPage "2653" @default.
• W3100773375 abstract "Protein aggregation, linked to many of diseases, is initiated when monomers access rogue conformations that are poised to form amyloid fibrils. We show, using simulations of src SH3 domain, that mechanical force enhances the population of the aggregation-prone (N⁎) states, which are rarely populated under force free native conditions but are encoded in the spectrum of native fluctuations. The folding phase diagrams of SH3 as a function of denaturant concentration ([C]), mechanical force (f), and temperature exhibit an apparent two-state behavior, without revealing the presence of the elusive N⁎ states. Interestingly, the phase boundaries separating the folded and unfolded states at all [C] and f fall on a master curve, which can be quantitatively described using an analogy to superconductors in a magnetic field. The free energy profiles as a function of the molecular extension (R), which are accessible in pulling experiments, (R), reveal the presence of a native-like N⁎ with a disordered solvent-exposed amino-terminal β-strand. The structure of the N⁎ state is identical with that found in Fyn SH3 by NMR dispersion experiments. We show that the timescale for fibril formation can be estimated from the population of the N⁎ state, determined by the free energy gap separating the native structure and the N⁎ state, a finding that can be used to assess fibril forming tendencies of proteins. The structures of the N⁎ state are used to show that oligomer formation and likely route to fibrils occur by a domain-swap mechanism in SH3 domain." @default.
• W3100773375 created "2020-11-23" @default.
• W3100773375 creator A5019118976 @default.
• W3100773375 creator A5036725653 @default.
• W3100773375 creator A5058069370 @default.
• W3100773375 creator A5075084768 @default.
• W3100773375 date "2014-07-01" @default.
• W3100773375 modified "2023-10-16" @default.
• W3100773375 title "Propensity to Form Amyloid Fibrils Is Encoded as Excitations in the Free Energy Landscape of Monomeric Proteins" @default.
• W3100773375 cites W1593625064 @default.
• W3100773375 cites W1593987163 @default.
• W3100773375 cites W1965366217 @default.
• W3100773375 cites W1970747152 @default.
• W3100773375 cites W1974105492 @default.
• W3100773375 cites W1977463239 @default.
• W3100773375 cites W1979761607 @default.
• W3100773375 cites W1980482609 @default.
• W3100773375 cites W1985297174 @default.
• W3100773375 cites W1987113547 @default.
• W3100773375 cites W1991267416 @default.
• W3100773375 cites W1991591212 @default.
• W3100773375 cites W1993085892 @default.
• W3100773375 cites W1999248724 @default.
• W3100773375 cites W1999824494 @default.
• W3100773375 cites W2004022676 @default.
• W3100773375 cites W2005426900 @default.
• W3100773375 cites W2006356944 @default.
• W3100773375 cites W2007374102 @default.
• W3100773375 cites W2014577263 @default.
• W3100773375 cites W2019465613 @default.
• W3100773375 cites W2019830467 @default.
• W3100773375 cites W2024473468 @default.
• W3100773375 cites W2027166643 @default.
• W3100773375 cites W2030315425 @default.
• W3100773375 cites W2035165231 @default.
• W3100773375 cites W2042090376 @default.
• W3100773375 cites W2048253059 @default.
• W3100773375 cites W2054930616 @default.
• W3100773375 cites W2058275547 @default.
• W3100773375 cites W2059820046 @default.
• W3100773375 cites W2066000489 @default.
• W3100773375 cites W2067236515 @default.
• W3100773375 cites W2074443308 @default.
• W3100773375 cites W2076713412 @default.
• W3100773375 cites W2083174976 @default.
• W3100773375 cites W2093861673 @default.
• W3100773375 cites W2096573717 @default.
• W3100773375 cites W2099092270 @default.
• W3100773375 cites W2099653907 @default.
• W3100773375 cites W2100847043 @default.
• W3100773375 cites W2102239681 @default.
• W3100773375 cites W2109610280 @default.
• W3100773375 cites W2112154906 @default.
• W3100773375 cites W2129507901 @default.
• W3100773375 cites W2132938122 @default.
• W3100773375 cites W2134439639 @default.
• W3100773375 cites W2145487893 @default.
• W3100773375 cites W2151916727 @default.
• W3100773375 cites W2159822943 @default.
• W3100773375 cites W2160721947 @default.
• W3100773375 cites W2164028467 @default.
• W3100773375 cites W2165186407 @default.
• W3100773375 cites W2172200231 @default.
• W3100773375 cites W2323178299 @default.
• W3100773375 cites W2329266475 @default.
• W3100773375 cites W4234862683 @default.
• W3100773375 doi "https://doi.org/10.1016/j.jmb.2014.05.007" @default.
• W3100773375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24846645" @default.
• W3100773375 hasPublicationYear "2014" @default.
• W3100773375 type Work @default.
• W3100773375 sameAs 3100773375 @default.
• W3100773375 citedByCount "54" @default.
• W3100773375 countsByYear W31007733752014 @default.
• W3100773375 countsByYear W31007733752015 @default.
• W3100773375 countsByYear W31007733752016 @default.
• W3100773375 countsByYear W31007733752017 @default.
• W3100773375 countsByYear W31007733752018 @default.
• W3100773375 countsByYear W31007733752019 @default.
• W3100773375 countsByYear W31007733752020 @default.
• W3100773375 countsByYear W31007733752021 @default.
• W3100773375 countsByYear W31007733752022 @default.
• W3100773375 countsByYear W31007733752023 @default.
• W3100773375 crossrefType "journal-article" @default.
• W3100773375 hasAuthorship W3100773375A5019118976 @default.
• W3100773375 hasAuthorship W3100773375A5036725653 @default.
• W3100773375 hasAuthorship W3100773375A5058069370 @default.
• W3100773375 hasAuthorship W3100773375A5075084768 @default.
• W3100773375 hasBestOaLocation W31007733752 @default.
• W3100773375 hasConcept C108636557 @default.
• W3100773375 hasConcept C119621388 @default.
• W3100773375 hasConcept C12554922 @default.
• W3100773375 hasConcept C144024400 @default.
• W3100773375 hasConcept C149923435 @default.
• W3100773375 hasConcept C159467904 @default.
• W3100773375 hasConcept C178790620 @default.
• W3100773375 hasConcept C184235292 @default.
• W3100773375 hasConcept C185592680 @default.
• W3100773375 hasConcept C19472624 @default.

• next