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• W3100776277 abstract "Toxoplasma gondii is a ubiquitous intracellular protozoan parasite that can cause severe and fatal disease in immunocompromised patients and the developing fetus. Rapid parasite replication is critical for establishing a productive infection. Here, we demonstrate that a Toxoplasma protein kinase called MAPK2 is conserved throughout the Alveolata and essential for parasite replication. We found that parasites lacking MAPK2 protein were defective in the initiation of daughter cell budding and were rendered inviable. Specifically, T. gondii MAPK2 (TgMAPK2) appears to be required for centrosome replication at the basal end of the nucleus, and its loss causes arrest early in parasite division. MAPK2 is unique to the Alveolata and not found in metazoa and likely is a critical component of an essential parasite-specific signaling network." @default.
• W3100776277 created "2020-11-23" @default.
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• W3100776277 date "2020-12-22" @default.
• W3100776277 modified "2023-09-23" @default.
• W3100776277 title "Loss of the Conserved Alveolate Kinase MAPK2 Decouples <i>Toxoplasma</i> Cell Growth from Cell Division" @default.
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• W3100776277 doi "https://doi.org/10.1128/mbio.02517-20" @default.
• W3100776277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7667025" @default.
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• W3100776277 hasPublicationYear "2020" @default.
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