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- W3100789542 abstract "Transaminases (TAs) offer an environmentally and economically attractive method for the direct synthesis of pharmaceutically relevant disubstituted 1-phenylpropan-2-amine derivatives starting from prochiral ketones. In this work, we report the application of immobilised whole-cell biocatalysts with (R)-transaminase activity for the synthesis of novel disubstituted 1-phenylpropan-2-amines. After optimisation of the asymmetric synthesis, the (R)-enantiomers could be produced with 88-89% conversion and >99% ee, while the (S)-enantiomers could be selectively obtained as the unreacted fraction of the corresponding racemic amines in kinetic resolution with >48% conversion and >95% ee." @default.
- W3100789542 created "2020-11-23" @default.
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- W3100789542 creator A5080686162 @default.
- W3100789542 date "2020-01-01" @default.
- W3100789542 modified "2023-10-17" @default.
- W3100789542 title "Transaminase-mediated synthesis of enantiopure drug-like 1-(3′,4′-disubstituted phenyl)propan-2-amines" @default.
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- W3100789542 doi "https://doi.org/10.1039/d0ra08134e" @default.
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