Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100793808> ?p ?o ?g. }
- W3100793808 endingPage "95" @default.
- W3100793808 startingPage "79" @default.
- W3100793808 abstract "The genetic code, once believed to be universal and immutable, is now known to contain many variations and is not quite universal. The basis for genome recoding strategy is genetic code variation that can be harnessed to improve cellular properties. Thus, genome recoding is a promising strategy for the enhancement of genome flexibility, allowing for novel functions that are not commonly documented in the organism in its natural environment. Here, the basic concept of genetic code and associated mechanisms for the generation of genetic codon variants, including biased codon usage, codon reassignment, and ambiguous decoding, are extensively discussed. Knowledge of the concept of natural genetic code expansion is also detailed. The generation of recoded organisms and associated mechanisms with basic targeting components, including aminoacyl-tRNA synthetase-tRNA pairs, elongation factor EF-Tu and ribosomes, are highlighted for a comprehensive understanding of this concept. The research associated with the generation of diverse recoded organisms is also discussed. The success of genome recoding in diverse multicellular organisms offers a platform for expanding protein chemistry at the biochemical level with non-canonical amino acids, genetically isolating the synthetic organisms from the natural ones, and fighting viruses, including SARS-CoV2, through the creation of attenuated viruses. In conclusion, genome recoding can offer diverse applications for improving cellular properties in the genome-recoded organisms." @default.
- W3100793808 created "2020-11-23" @default.
- W3100793808 creator A5017090566 @default.
- W3100793808 creator A5073323336 @default.
- W3100793808 creator A5077928677 @default.
- W3100793808 creator A5090342082 @default.
- W3100793808 date "2020-11-19" @default.
- W3100793808 modified "2023-10-12" @default.
- W3100793808 title "Genome recoding strategies to improve cellular properties: mechanisms and advances" @default.
- W3100793808 cites W1164192234 @default.
- W3100793808 cites W1216718361 @default.
- W3100793808 cites W144210158 @default.
- W3100793808 cites W146770935 @default.
- W3100793808 cites W1502060396 @default.
- W3100793808 cites W1579705794 @default.
- W3100793808 cites W1666992502 @default.
- W3100793808 cites W1919707350 @default.
- W3100793808 cites W1963724731 @default.
- W3100793808 cites W1965815487 @default.
- W3100793808 cites W1969330612 @default.
- W3100793808 cites W1969449009 @default.
- W3100793808 cites W1974248650 @default.
- W3100793808 cites W1975782217 @default.
- W3100793808 cites W1976678081 @default.
- W3100793808 cites W1979275335 @default.
- W3100793808 cites W1985037876 @default.
- W3100793808 cites W1986211431 @default.
- W3100793808 cites W1992486617 @default.
- W3100793808 cites W1993419746 @default.
- W3100793808 cites W1994839146 @default.
- W3100793808 cites W1995143868 @default.
- W3100793808 cites W2001674944 @default.
- W3100793808 cites W2004963253 @default.
- W3100793808 cites W2007823563 @default.
- W3100793808 cites W2020320704 @default.
- W3100793808 cites W2023515240 @default.
- W3100793808 cites W2024335508 @default.
- W3100793808 cites W2025121505 @default.
- W3100793808 cites W2025569664 @default.
- W3100793808 cites W2028466606 @default.
- W3100793808 cites W2030564603 @default.
- W3100793808 cites W2039295326 @default.
- W3100793808 cites W2041034033 @default.
- W3100793808 cites W2041949408 @default.
- W3100793808 cites W2043249509 @default.
- W3100793808 cites W2047224020 @default.
- W3100793808 cites W2047289660 @default.
- W3100793808 cites W2051947456 @default.
- W3100793808 cites W2053370210 @default.
- W3100793808 cites W2054000323 @default.
- W3100793808 cites W2054218850 @default.
- W3100793808 cites W2057830027 @default.
- W3100793808 cites W2057892106 @default.
- W3100793808 cites W2058079617 @default.
- W3100793808 cites W2058867258 @default.
- W3100793808 cites W2060391020 @default.
- W3100793808 cites W2062758560 @default.
- W3100793808 cites W2066829062 @default.
- W3100793808 cites W2071932815 @default.
- W3100793808 cites W2072284352 @default.
- W3100793808 cites W2074933455 @default.
- W3100793808 cites W2076946494 @default.
- W3100793808 cites W2076992251 @default.
- W3100793808 cites W2077024527 @default.
- W3100793808 cites W2078880863 @default.
- W3100793808 cites W2079517684 @default.
- W3100793808 cites W2080064417 @default.
- W3100793808 cites W2085029536 @default.
- W3100793808 cites W2085042048 @default.
- W3100793808 cites W2088501568 @default.
- W3100793808 cites W2094952096 @default.
- W3100793808 cites W2095370301 @default.
- W3100793808 cites W2095911028 @default.
- W3100793808 cites W2097143603 @default.
- W3100793808 cites W2107167859 @default.
- W3100793808 cites W2119490692 @default.
- W3100793808 cites W2120253101 @default.
- W3100793808 cites W2121646171 @default.
- W3100793808 cites W2122618891 @default.
- W3100793808 cites W2140425855 @default.
- W3100793808 cites W2142138683 @default.
- W3100793808 cites W2144296712 @default.
- W3100793808 cites W2144371011 @default.
- W3100793808 cites W2145273188 @default.
- W3100793808 cites W2147603318 @default.
- W3100793808 cites W2148123458 @default.
- W3100793808 cites W2149172763 @default.
- W3100793808 cites W2157680389 @default.
- W3100793808 cites W2157848631 @default.
- W3100793808 cites W2160979138 @default.
- W3100793808 cites W2161109755 @default.
- W3100793808 cites W2163266294 @default.
- W3100793808 cites W2186868783 @default.
- W3100793808 cites W2298792983 @default.
- W3100793808 cites W2336675821 @default.
- W3100793808 cites W2462560104 @default.
- W3100793808 cites W2474493646 @default.
- W3100793808 cites W2512706593 @default.