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- W3100806974 abstract "Purpose: To evaluate the osteogenic properties of a bioglass-doxycycline complex for bone regeneration applications in calvarial bone defects in rats.Methods: Three critical-size bone defects were created in each of eight experimental rats using a trephine bur. The experimentally created defects were then filled with bioglass-doxycycline (BG-D group), bioglass alone (BG group), or left unfilled (control group). Four randomly selected rats weresacrificed after 4 weeks while the other four rats were sacrificed after 8 weeks. The amount of newly regenerated bone and the osteoblast and osteoclast counts were calculated using histological analysis.Results: Increase in the amount of regenerated bone was significant in the bioglass-doxycycline group at both 4 and 8 weeks (p < 0.05). Differences between the three groups in the mean number of osteoblasts were also significant at both 4 and 8 weeks (p < 0.05). Comparison of the three groupsrevealed significant increase in osteogenesis rate and considerable enhancement of the number of osteoblasts in both bioglass and bioglass-doxycycline groups (p < 0.05).Conclusion: The complex of doxycycline and bioglass increased the rate of osteogenesis and number of osteoblasts in rats but decreased the number of osteoclasts. Therefore, bioglass-doxycycline can be considered as a bone graft in bone regeneration for medical applications.
 Keywords: Bone, Regeneration, Osteoblasts, Osteoclasts, Osteogenesis, Bioglass, Doxycycline" @default.
- W3100806974 created "2020-11-23" @default.
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- W3100806974 date "2020-11-13" @default.
- W3100806974 modified "2023-10-17" @default.
- W3100806974 title "Effect of doxycycline-bioglass treatment on calvarial bone defect in rats: A histological study" @default.
- W3100806974 doi "https://doi.org/10.4314/tjpr.v19i6.19" @default.
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