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- W3100808483 abstract "The small and diffusible free radical nitric oxide (•NO) has fascinated biological and medical scientists since it was promoted from atmospheric air pollutant to biological ubiquitous signaling molecule. Its unique physical chemical properties expand beyond its radical nature to include fast diffusion in aqueous and lipid environments and selective reactivity in a biological setting determined by bioavailability and reaction rate constants with biomolecules. In the brain, •NO is recognized as a key player in numerous physiological processes ranging from neurotransmission/neuromodulation to neurovascular coupling and immune response. Furthermore, changes in its bioactivity are central to the molecular pathways associated with brain aging and neurodegeneration. The understanding of •NO bioactivity in the brain, however, requires the knowledge of its concentration dynamics with high spatial and temporal resolution upon stimulation of its synthesis. Here we revise our current understanding of the role of neuronal-derived •NO in brain physiology, aging and degeneration, focused on changes in the extracellular concentration dynamics of this free radical and the regulation of bioenergetic metabolism and neurovascular coupling." @default.
- W3100808483 created "2020-11-23" @default.
- W3100808483 creator A5003921163 @default.
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- W3100808483 creator A5056159724 @default.
- W3100808483 creator A5057583048 @default.
- W3100808483 creator A5090186962 @default.
- W3100808483 date "2021-01-01" @default.
- W3100808483 modified "2023-10-16" @default.
- W3100808483 title "The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: Switching signaling to degeneration" @default.
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