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- W3100808943 endingPage "5390" @default.
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- W3100808943 abstract "Free radicals, generally composed of reactive oxygen species (ROS) and reactive nitrogen species (RNS), are generated in the body by various endogenous and exogenous systems. The overproduction of free radicals is known to cause several chronic diseases including cancer. However, increased production of free radicals by chemotherapeutic drugs is also associated with apoptosis in cancer cells, indicating the dual nature of free radicals. Among various natural compounds, curcumin manifests as an antioxidant in normal cells that helps in the prevention of carcinogenesis. It also acts as a prooxidant in cancer cells and is associated with inducing apoptosis. Curcumin quenches free radicals, induces antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase), and upregulates antioxidative protein markers–Nrf2 and HO-1 that lead to the suppression of cellular oxidative stress. In cancer cells, curcumin aggressively increases ROS that results in DNA damage and subsequently cancer cell death. It also sensitizes drug-resistant cancer cells and increases the anticancer effects of chemotherapeutic drugs. Thus, curcumin shows beneficial effects in prevention, treatment and chemosensitization of cancer cells. In this review, we will discuss the dual role of free radicals as well as the chemopreventive and chemotherapeutic effects of curcumin and its analogues against cancer." @default.
- W3100808943 created "2020-11-23" @default.
- W3100808943 creator A5026614056 @default.
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- W3100808943 creator A5050029453 @default.
- W3100808943 creator A5071653773 @default.
- W3100808943 creator A5076779798 @default.
- W3100808943 creator A5086775713 @default.
- W3100808943 date "2020-11-18" @default.
- W3100808943 modified "2023-10-01" @default.
- W3100808943 title "Free Radicals as a Double-Edged Sword: The Cancer Preventive and Therapeutic Roles of Curcumin" @default.
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