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- W3100811344 abstract "Cardiovascular disease is a major cause of morbidity and mortality in patients with chronic kidney disease (CKD). Myocardial oxygenation and perfusion response to stress, using oxygen-sensitive cardiovascular magnetic resonance (OS-CMR) and stress T1 mapping respectively, are impaired in CKD patients with and without known CAD. Serum Asymmetric Dimethylarginine (ADMA) inhibits nitric oxide synthesis and therefore impairs endothelial function. Homoarginine (HMA) may increase nitric oxide availability and enhance endothelial function. In CKD patients, higher levels of ADMA and lower levels of HMA are associated with worsening myocardial oxygenation and perfusion as assessed by change in OS-CMR signal intensity (Δ OS-CMR SI) and stress T1 (ΔT1) values. 38 patients with CKD (13 with known CAD, 26 males) aged 62.8±13.5 years were included if they had severe renal failure as defined by an eGFR<30 mL/min/1.73 m2, or were requiring dialysis, or had a previous renal transplant. OS-CMR and T1 mapping images were acquired both at rest and after adenosine stress and analyzed semi-quantitatively. Serum ADMA and HMA concentrations were assessed using mass spectrometry. After adjusting for age, gender, body mass index, C-reactive protein and troponin T, there was no significant correlation between Δ OS-CMR SI and ADMA or HMA. Interestingly, there was a significant negative correlation seen between Δ T1 and ADMA (r=-0.419, p=0.037, n=30) but not between Δ T1 and HMA. Stress T1 response is impaired in CKD patients and is independently associated with higher circulating ADMA concentrations." @default.
- W3100811344 created "2020-11-23" @default.
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- W3100811344 date "2020-01-01" @default.
- W3100811344 modified "2023-10-18" @default.
- W3100811344 title "290 Arginine Analogues as Biomarkers of Myocardial Ischaemia, Assessed with Cardiac Magnetic Resonance in Chronic Kidney Disease" @default.
- W3100811344 doi "https://doi.org/10.1016/j.hlc.2020.09.297" @default.
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