FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100831279> ?p ?o ?g. }

• W3100831279 abstract "Biomaterials serve as the basis of implants, tissue engineering scaffolds, and multiple other biomedical therapeutics. New technologies, such as single cell RNA sequencing (scRNAseq), are enabling characterization of the biomaterial response to an unprecedented level of detail, facilitating new discoveries in the complex cellular environment surrounding materials. We performed scRNAseq and integrated data sets from multiple experiments to create a single cell atlas of the biomaterials response that contains 42,156 cells from biological extracellular matrix (ECM)-derived and synthetic polyester (polycaprolactone, PCL) scaffold biomaterials implanted in murine muscle wounds. We identified 18 clusters of cells, including natural killer (NK) cells, multiple subsets of fibroblasts, and myeloid cells, many of which were previously unknown in the biomaterial response. To determine intra and intercellular signaling occurring between the numerous cell subsets, including immune-stromal interactions in the biomaterial response, we developed Domino (github.com/chris-cherry/domino), a computational tool which allows for identification of condition specific intercellular signaling patterns connected to transcription factor activation from single cell data. The Domino networks self-assembled into signaling modules and cellular subsets involved in signaling independent of clustering, defining interactions between immune, fibroblast, and tissue-specific modules with biomaterials-specific communication patterns. Further compilation and integration of biomaterials single cell data sets will delineate the impact of materials chemical and physical properties and biological factors, such as anatomical placement, age, or systemic disease, that will direct biomaterials design." @default.
• W3100831279 created "2020-11-23" @default.
• W3100831279 creator A5003097757 @default.
• W3100831279 creator A5004108540 @default.
• W3100831279 creator A5005523854 @default.
• W3100831279 creator A5017494930 @default.
• W3100831279 creator A5024978163 @default.
• W3100831279 creator A5048377951 @default.
• W3100831279 creator A5057408888 @default.
• W3100831279 creator A5076970480 @default.
• W3100831279 date "2020-07-25" @default.
• W3100831279 modified "2023-09-23" @default.
• W3100831279 title "Intercellular signaling dynamics from a single cell atlas of the biomaterials response" @default.
• W3100831279 cites W1487322990 @default.
• W3100831279 cites W1974913190 @default.
• W3100831279 cites W1981547140 @default.
• W3100831279 cites W1995063875 @default.
• W3100831279 cites W1999353686 @default.
• W3100831279 cites W2008565536 @default.
• W3100831279 cites W2045949302 @default.
• W3100831279 cites W2054012997 @default.
• W3100831279 cites W2054875722 @default.
• W3100831279 cites W2068242732 @default.
• W3100831279 cites W2069089843 @default.
• W3100831279 cites W2071859846 @default.
• W3100831279 cites W2103722820 @default.
• W3100831279 cites W2151328705 @default.
• W3100831279 cites W2160247072 @default.
• W3100831279 cites W2170830993 @default.
• W3100831279 cites W2336642884 @default.
• W3100831279 cites W2538287657 @default.
• W3100831279 cites W2564443347 @default.
• W3100831279 cites W2616922646 @default.
• W3100831279 cites W2743416243 @default.
• W3100831279 cites W2766765760 @default.
• W3100831279 cites W2770062015 @default.
• W3100831279 cites W2781484625 @default.
• W3100831279 cites W2805415936 @default.
• W3100831279 cites W2805643833 @default.
• W3100831279 cites W2886103315 @default.
• W3100831279 cites W2894687190 @default.
• W3100831279 cites W2896222795 @default.
• W3100831279 cites W2900044275 @default.
• W3100831279 cites W2908139053 @default.
• W3100831279 cites W2912374833 @default.
• W3100831279 cites W2912696928 @default.
• W3100831279 cites W2944372903 @default.
• W3100831279 cites W2949243209 @default.
• W3100831279 cites W2951520325 @default.
• W3100831279 cites W2960029024 @default.
• W3100831279 cites W2979909244 @default.
• W3100831279 cites W2982688482 @default.
• W3100831279 cites W2984472267 @default.
• W3100831279 cites W2991414673 @default.
• W3100831279 cites W2992151131 @default.
• W3100831279 cites W3007935255 @default.
• W3100831279 cites W3009797991 @default.
• W3100831279 cites W3016488923 @default.
• W3100831279 cites W3044190151 @default.
• W3100831279 cites W4213108508 @default.
• W3100831279 cites W603338907 @default.
• W3100831279 doi "https://doi.org/10.1101/2020.07.24.218537" @default.
• W3100831279 hasPublicationYear "2020" @default.
• W3100831279 type Work @default.
• W3100831279 sameAs 3100831279 @default.
• W3100831279 citedByCount "5" @default.
• W3100831279 countsByYear W31008312792021 @default.
• W3100831279 countsByYear W31008312792022 @default.
• W3100831279 countsByYear W31008312792023 @default.
• W3100831279 crossrefType "posted-content" @default.
• W3100831279 hasAuthorship W3100831279A5003097757 @default.
• W3100831279 hasAuthorship W3100831279A5004108540 @default.
• W3100831279 hasAuthorship W3100831279A5005523854 @default.
• W3100831279 hasAuthorship W3100831279A5017494930 @default.
• W3100831279 hasAuthorship W3100831279A5024978163 @default.
• W3100831279 hasAuthorship W3100831279A5048377951 @default.
• W3100831279 hasAuthorship W3100831279A5057408888 @default.
• W3100831279 hasAuthorship W3100831279A5076970480 @default.
• W3100831279 hasBestOaLocation W31008312791 @default.
• W3100831279 hasConcept C136229726 @default.
• W3100831279 hasConcept C1491633281 @default.
• W3100831279 hasConcept C150555746 @default.
• W3100831279 hasConcept C171250308 @default.
• W3100831279 hasConcept C185592680 @default.
• W3100831279 hasConcept C189165786 @default.
• W3100831279 hasConcept C192562407 @default.
• W3100831279 hasConcept C198826908 @default.
• W3100831279 hasConcept C2778414984 @default.
• W3100831279 hasConcept C49892992 @default.
• W3100831279 hasConcept C55493867 @default.
• W3100831279 hasConcept C62478195 @default.
• W3100831279 hasConcept C71924100 @default.
• W3100831279 hasConcept C86803240 @default.
• W3100831279 hasConcept C95444343 @default.
• W3100831279 hasConceptScore W3100831279C136229726 @default.
• W3100831279 hasConceptScore W3100831279C1491633281 @default.
• W3100831279 hasConceptScore W3100831279C150555746 @default.
• W3100831279 hasConceptScore W3100831279C171250308 @default.
• W3100831279 hasConceptScore W3100831279C185592680 @default.
• W3100831279 hasConceptScore W3100831279C189165786 @default.

• next