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- W3100835132 abstract "Background: Cystic echinococcosis is a frequent worldwide disease. Surgery is the main policy oftreatment. The benzimidazoles are the drugs of choice as adjuvant therapy besides surgery, but they havesome drawbacks, so there is a pressing need to develop other safe and cheap drugs such as an herbalextract.Objectives: To increase the efficacy of Nigella sativa oil (NSO) administered either as monotherapy orcombined with albendazole, and using chitosan nanoparticles as a drug delivery system for both drugs.Material and Methods: E. granulosus protoscoleces were obtained by aseptic puncture of hydatidcysts. Mice infected by intraperitoneal inoculation with nearly 1000 protoscoleces per mouse weresubdivided into 7 groups: G2, infected non-treated; G3, treated with albendazole; G4, treated with NSO;G5, treated with NSO and albendazole; G6, treated with albendazole loaded on chitosan nanoparticles;G7, treated with NSO loaded on chitosan nanoparticles; G8, treated with albendazole and NSO loaded onchitosan nanoparticles. G1 included the non-infected, non-treated control mice. Serum was collected forbiochemical and serological assay. NO was measured according to nitric oxide assay colorimetric kit. Thesystemic level of TNF-α and IL-5 was determined in the plasma of mice using commercial enzyme-linkedimmunosorbent assay kits.Results: The results revealed that a significant increase of IL-5 occurred in all treated groups to reach thehighest value in G8. There was a significant decrease of TNF-α in all treated groups in comparison to G1and G2 (P<0.001). Mean level of nitric oxide (NO) was significantly increased in groups loaded on chitosannanoparticles in comparison to G2.Conclusion: Nigella sativa oil showed a promising effect on CE when used alone or in combination withalbendazole and its effect was augmented when loaded on chitosan nanoparticles." @default.
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- W3100835132 date "2020-12-01" @default.
- W3100835132 modified "2023-10-14" @default.
- W3100835132 title "Efficacy of Nigella sativa oil and its chitosan loaded nanoparticles on experimental cystic echinoncoccosis with immunological assessment" @default.
- W3100835132 doi "https://doi.org/10.21608/puj.2020.41053.1086" @default.
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