Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100842417> ?p ?o ?g. }
- W3100842417 abstract "ABSTRACT Neuronal extracellular vesicles (EVs) play important roles in intercellular communication and pathogenic protein propagation in neurological disease. However, it remains unclear how cargoes are selectively packaged into neuronal EVs. Here, we show that loss of the endosomal retromer complex leads to accumulation of EV cargoes Amyloid Precursor Protein (APP) and Synaptotagmin-4 (Syt4) at Drosophila motor neuron presynaptic terminals, resulting in increased release of these cargoes in EVs. By systematically exploring known retromer-dependent trafficking mechanisms, we show that EV regulation is separable from several previously identified roles of neuronal retromer, and depends on the ESCPE-1 complex. Conversely, loss of the recycling endosome regulator rab11 leads to reduced EV cargo levels, and suppresses cargo accumulation in retromer mutants. Thus, EV traffic reflects a balance between Rab11-mediated loading and retromer-dependent removal from EV precursor compartments. Our data shed light on previous studies implicating Rab11 and retromer in competing pathways in Alzheimer’s Disease, and suggest that misregulated EV traffic may be an underlying defect." @default.
- W3100842417 created "2020-11-23" @default.
- W3100842417 creator A5004983690 @default.
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- W3100842417 creator A5031799168 @default.
- W3100842417 creator A5043807672 @default.
- W3100842417 creator A5047601551 @default.
- W3100842417 creator A5057939599 @default.
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- W3100842417 creator A5077397465 @default.
- W3100842417 creator A5082624355 @default.
- W3100842417 creator A5088434593 @default.
- W3100842417 date "2019-05-21" @default.
- W3100842417 modified "2023-09-26" @default.
- W3100842417 title "Opposing functions for retromer and Rab11 in extracellular vesicle cargo traffic at presynaptic terminals" @default.
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