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- W3100843481 abstract "Introduction: Although life-threatening if left untreated, visceral leishmaniasis (VL) is still a neglected endemic disease in 98 countries worldwide. The number of drugs available is low and few are in clinical trials. In the last decades, efforts have been made on the development of nanocarriers as drug delivery systems to treat VL. Given the preferential intracellular location of the parasite in the liver and spleen macrophages, the rationale is sturdy. In a clinical setting, liposomal amphotericin B displays astonishing cure rates.Areas covered: A literature search was performed through PubMed and Google Scholar. We critically reviewed the main literature highlighting the success of nanomedicine in VL. We also reviewed the hurdles and yet unfulfilled promises rising awareness of potential drawbacks of nanomedicine in VL.Expert opinion: VL is a disease where nanomedicines successes shine through. However, there are a lot of obstacles on the road to developing more efficient strategies such as targeting functionalization, oral formulations, or combined therapies. And those strategies raise many questions." @default.
- W3100843481 created "2020-11-23" @default.
- W3100843481 creator A5022406062 @default.
- W3100843481 creator A5028438452 @default.
- W3100843481 creator A5032114885 @default.
- W3100843481 creator A5032466294 @default.
- W3100843481 date "2020-12-14" @default.
- W3100843481 modified "2023-10-18" @default.
- W3100843481 title "The advantages of nanomedicine in the treatment of visceral leishmaniasis: between sound arguments and wishful thinking" @default.
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