FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100846097> ?p ?o ?g. }

• W3100846097 abstract "Abstract Salivary glands (SGs) are very important for maintaining the physiological functions of the mouth. When SGs regenerate and repair from various damages, including mechanical, radiological, and immune diseases, acinar and granular duct cells originate from intercalated duct cells. However, the recovery is often insufficient because of SGs' limited self-repair function. Furthermore, the precise repair mechanism has been unclear. Here, we focused on CD49f, one of the putative stem cell markers, and characterized CD49f positive cells (CD49f + cells) isolated from male murine SGs. CD49f + cells possess self-renewal ability and express epithelial and pluripotent markers. Compared to CD49f negative cells, freshly isolated CD49f + cells highly expressed inhibin beta A and beta B, which are components of activin that has anti-proliferative effects. Notably, an inhibitor of activin, follistatin was expressed in mechanically-damaged SGs, meanwhile no follistatin was expressed in normal SGs in vivo. Moreover, sub-cultured CD49f + cells highly expressed both Follistatin and a series of proliferative genes, expressions of which were decreased by Follistatin siRNA. These findings indicated that the molecular interaction between activin and follistatin may induce CD49f + cells proliferation in the regeneration and repair of mouse SGs." @default.
• W3100846097 created "2020-11-23" @default.
• W3100846097 creator A5022185367 @default.
• W3100846097 creator A5022288614 @default.
• W3100846097 creator A5049686289 @default.
• W3100846097 creator A5054823334 @default.
• W3100846097 date "2020-11-17" @default.
• W3100846097 modified "2023-10-17" @default.
• W3100846097 title "Follistatin expressed in mechanically-damaged salivary glands of male mice induces proliferation of CD49f+ cells" @default.
• W3100846097 cites W1483657826 @default.
• W3100846097 cites W1518504057 @default.
• W3100846097 cites W1563959780 @default.
• W3100846097 cites W1768073869 @default.
• W3100846097 cites W1966514705 @default.
• W3100846097 cites W1973015833 @default.
• W3100846097 cites W1978628059 @default.
• W3100846097 cites W1986018115 @default.
• W3100846097 cites W1989748343 @default.
• W3100846097 cites W1992216512 @default.
• W3100846097 cites W1997153927 @default.
• W3100846097 cites W1999061629 @default.
• W3100846097 cites W2003047394 @default.
• W3100846097 cites W2007333291 @default.
• W3100846097 cites W2014339782 @default.
• W3100846097 cites W2015260698 @default.
• W3100846097 cites W2017177010 @default.
• W3100846097 cites W2024019881 @default.
• W3100846097 cites W2033077654 @default.
• W3100846097 cites W2033158024 @default.
• W3100846097 cites W2042217942 @default.
• W3100846097 cites W2051197697 @default.
• W3100846097 cites W2055698728 @default.
• W3100846097 cites W2060889469 @default.
• W3100846097 cites W2074315922 @default.
• W3100846097 cites W2083632015 @default.
• W3100846097 cites W2090400324 @default.
• W3100846097 cites W2095397371 @default.
• W3100846097 cites W2105031631 @default.
• W3100846097 cites W2120951319 @default.
• W3100846097 cites W2122439512 @default.
• W3100846097 cites W2133982448 @default.
• W3100846097 cites W2136022401 @default.
• W3100846097 cites W2137621685 @default.
• W3100846097 cites W2144805836 @default.
• W3100846097 cites W2149066998 @default.
• W3100846097 cites W2150095569 @default.
• W3100846097 cites W2152059851 @default.
• W3100846097 cites W2159047060 @default.
• W3100846097 cites W2159133270 @default.
• W3100846097 cites W2168211018 @default.
• W3100846097 cites W2184430395 @default.
• W3100846097 cites W2460662933 @default.
• W3100846097 cites W2782973755 @default.
• W3100846097 cites W2802516505 @default.
• W3100846097 cites W2891683811 @default.
• W3100846097 cites W2918080711 @default.
• W3100846097 cites W2965148899 @default.
• W3100846097 cites W4252030004 @default.
• W3100846097 doi "https://doi.org/10.1038/s41598-020-77004-2" @default.
• W3100846097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7673039" @default.
• W3100846097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33203957" @default.
• W3100846097 hasPublicationYear "2020" @default.
• W3100846097 type Work @default.
• W3100846097 sameAs 3100846097 @default.
• W3100846097 citedByCount "1" @default.
• W3100846097 countsByYear W31008460972022 @default.
• W3100846097 crossrefType "journal-article" @default.
• W3100846097 hasAuthorship W3100846097A5022185367 @default.
• W3100846097 hasAuthorship W3100846097A5022288614 @default.
• W3100846097 hasAuthorship W3100846097A5049686289 @default.
• W3100846097 hasAuthorship W3100846097A5054823334 @default.
• W3100846097 hasBestOaLocation W31008460971 @default.
• W3100846097 hasConcept C104317684 @default.
• W3100846097 hasConcept C107459253 @default.
• W3100846097 hasConcept C145103041 @default.
• W3100846097 hasConcept C185592680 @default.
• W3100846097 hasConcept C2778831791 @default.
• W3100846097 hasConcept C502942594 @default.
• W3100846097 hasConcept C54355233 @default.
• W3100846097 hasConcept C55493867 @default.
• W3100846097 hasConcept C62112901 @default.
• W3100846097 hasConcept C86803240 @default.
• W3100846097 hasConcept C95444343 @default.
• W3100846097 hasConceptScore W3100846097C104317684 @default.
• W3100846097 hasConceptScore W3100846097C107459253 @default.
• W3100846097 hasConceptScore W3100846097C145103041 @default.
• W3100846097 hasConceptScore W3100846097C185592680 @default.
• W3100846097 hasConceptScore W3100846097C2778831791 @default.
• W3100846097 hasConceptScore W3100846097C502942594 @default.
• W3100846097 hasConceptScore W3100846097C54355233 @default.
• W3100846097 hasConceptScore W3100846097C55493867 @default.
• W3100846097 hasConceptScore W3100846097C62112901 @default.
• W3100846097 hasConceptScore W3100846097C86803240 @default.
• W3100846097 hasConceptScore W3100846097C95444343 @default.
• W3100846097 hasIssue "1" @default.
• W3100846097 hasLocation W31008460971 @default.
• W3100846097 hasLocation W31008460972 @default.
• W3100846097 hasLocation W31008460973 @default.
• W3100846097 hasOpenAccess W3100846097 @default.
• W3100846097 hasPrimaryLocation W31008460971 @default.

• next