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- W3100865865 abstract "ABSTRACT Neural decoding and neuromodulation technologies hold great promise for treating mood and other brain disorders in next-generation therapies that manipulate functional brain networks. Here, we perform a novel causal network analysis to decode multiregional communication in the primate mood processing network and determine how neuromodulation, short-burst tetanic microstimulation (SB-TetMS), alters multiregional network communication. The causal network analysis revealed a mechanism of network excitability that regulates when a sender stimulation site communicates with receiver sites. Decoding network excitability from neural activity at modulator sites predicted sender-receiver communication while SB-TetMS neuromodulation specifically disrupted sender-receiver communication. These results reveal specific network mechanisms of multiregional communication and suggest a new generation of brain therapies that combine neural decoding to predict multiregional communication with neuromodulation to disrupt multiregional communication. One Sentence Summary Decoding and modulating multiregional network communication." @default.
- W3100865865 created "2020-11-23" @default.
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- W3100865865 date "2019-08-10" @default.
- W3100865865 modified "2023-10-16" @default.
- W3100865865 title "Decoding and modulating multiregional communication in the mood processing network" @default.
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- W3100865865 doi "https://doi.org/10.1101/731547" @default.
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