Matches in SemOpenAlex for { <https://semopenalex.org/work/W3100866785> ?p ?o ?g. }
- W3100866785 endingPage "33" @default.
- W3100866785 startingPage "19" @default.
- W3100866785 abstract "Acute graft-versus-host disease (GVHD), the major complication after allogeneic hematopoietic cell transplant (HCT), develops in approximately 50% of patients. The primary treatment is high-dose systemic steroids, but treatment failure is common, and steroid-refractory (SR) GVHD is the leading cause of non-relapse mortality after allogeneic HCT. Ruxolitinib became the first treatment for SR GVHD to obtain US Food and Drug Administration approval, and other new treatments are actively being studied. We searched the literature using the PubMed database and clinical trials using ClinicalTrials.gov to identify the most promising new treatments for GVHD. In this review, we categorize potential new treatments for GVHD by their mechanism of action (e.g., antibodies that deplete T cells or prevent their trafficking to target tissues, proteasome inhibitors, tyrosine kinase inhibitors, and other agents) and summarize the results from clinical trials." @default.
- W3100866785 created "2020-11-23" @default.
- W3100866785 creator A5019838870 @default.
- W3100866785 creator A5043877705 @default.
- W3100866785 creator A5047902466 @default.
- W3100866785 date "2020-11-17" @default.
- W3100866785 modified "2023-10-12" @default.
- W3100866785 title "Current and Emerging Targeted Therapies for Acute Graft-Versus-Host Disease" @default.
- W3100866785 cites W1561150462 @default.
- W3100866785 cites W1591020799 @default.
- W3100866785 cites W1676794103 @default.
- W3100866785 cites W1689714760 @default.
- W3100866785 cites W1731519232 @default.
- W3100866785 cites W1776520887 @default.
- W3100866785 cites W1974508346 @default.
- W3100866785 cites W1978635205 @default.
- W3100866785 cites W1992747398 @default.
- W3100866785 cites W1998633680 @default.
- W3100866785 cites W1999834650 @default.
- W3100866785 cites W2000487018 @default.
- W3100866785 cites W2001533977 @default.
- W3100866785 cites W2008423270 @default.
- W3100866785 cites W2014381340 @default.
- W3100866785 cites W2017295150 @default.
- W3100866785 cites W2022664029 @default.
- W3100866785 cites W2037163385 @default.
- W3100866785 cites W2044022462 @default.
- W3100866785 cites W2049400198 @default.
- W3100866785 cites W2049460956 @default.
- W3100866785 cites W2049774501 @default.
- W3100866785 cites W2057793072 @default.
- W3100866785 cites W2059099306 @default.
- W3100866785 cites W2060870565 @default.
- W3100866785 cites W2071430789 @default.
- W3100866785 cites W2077531651 @default.
- W3100866785 cites W2077719208 @default.
- W3100866785 cites W2093864281 @default.
- W3100866785 cites W2094953165 @default.
- W3100866785 cites W2098345971 @default.
- W3100866785 cites W2103758700 @default.
- W3100866785 cites W2104795683 @default.
- W3100866785 cites W2118775039 @default.
- W3100866785 cites W2121743767 @default.
- W3100866785 cites W2132173287 @default.
- W3100866785 cites W2138946470 @default.
- W3100866785 cites W2144491171 @default.
- W3100866785 cites W2144789671 @default.
- W3100866785 cites W2154268960 @default.
- W3100866785 cites W2169872175 @default.
- W3100866785 cites W2175887431 @default.
- W3100866785 cites W2195777839 @default.
- W3100866785 cites W2238141562 @default.
- W3100866785 cites W2242967291 @default.
- W3100866785 cites W2261920671 @default.
- W3100866785 cites W2347098804 @default.
- W3100866785 cites W2394719613 @default.
- W3100866785 cites W2400645104 @default.
- W3100866785 cites W2405712018 @default.
- W3100866785 cites W2558050630 @default.
- W3100866785 cites W2558668988 @default.
- W3100866785 cites W2561691755 @default.
- W3100866785 cites W2570562006 @default.
- W3100866785 cites W2595098826 @default.
- W3100866785 cites W2597974085 @default.
- W3100866785 cites W2598479043 @default.
- W3100866785 cites W2611579691 @default.
- W3100866785 cites W2623565822 @default.
- W3100866785 cites W2746681845 @default.
- W3100866785 cites W2752993654 @default.
- W3100866785 cites W2757349481 @default.
- W3100866785 cites W2759277150 @default.
- W3100866785 cites W2769222378 @default.
- W3100866785 cites W2785331260 @default.
- W3100866785 cites W2791316427 @default.
- W3100866785 cites W2792936145 @default.
- W3100866785 cites W2792985650 @default.
- W3100866785 cites W2793526309 @default.
- W3100866785 cites W2795895428 @default.
- W3100866785 cites W2796282781 @default.
- W3100866785 cites W2800219125 @default.
- W3100866785 cites W2800702115 @default.
- W3100866785 cites W2803429008 @default.
- W3100866785 cites W2805930313 @default.
- W3100866785 cites W2886776552 @default.
- W3100866785 cites W2897264084 @default.
- W3100866785 cites W2899291216 @default.
- W3100866785 cites W2900744589 @default.
- W3100866785 cites W2909749644 @default.
- W3100866785 cites W2911968028 @default.
- W3100866785 cites W2917040403 @default.
- W3100866785 cites W2943094036 @default.
- W3100866785 cites W2943721858 @default.
- W3100866785 cites W2972161970 @default.
- W3100866785 cites W2974694426 @default.
- W3100866785 cites W2986517919 @default.
- W3100866785 cites W2987639915 @default.
- W3100866785 cites W2987752047 @default.
- W3100866785 cites W3001829780 @default.