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- W3100869870 abstract "We herein report, a practical and efficient strategy for the synthesis of enantiomerically enriched 2‐amino‐1‐arylethanols, a structural motif commonly encountered in the family of β‐adrenergic blockers or agonists, through a Lewis base‐catalyzed SiCl 4 ‐mediated asymmetric Passerini‐type reaction of isocyanides with aldehydes. The protocol features a simple one‐pot, two‐step procedure, the use of commercially available starting materials, a broad functional group tolerance, and high levels of selectivity up to 98.5:1.5 er . Application to the synthesis of the salbutamol acetate salt, a drug widely used as a bronchodilator to manage asthma and other chronic obstructive airway diseases is also reported." @default.
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- W3100869870 date "2020-10-28" @default.
- W3100869870 modified "2023-09-25" @default.
- W3100869870 title "Efficient Synthesis of 2‐Amino‐1‐Arylethanols Through a Lewis Base‐Catalyzed SiCl <sub>4</sub> ‐Mediated Asymmetric Passerini‐Type Reaction" @default.
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- W3100869870 doi "https://doi.org/10.1002/ejoc.202001172" @default.
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