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- W3100888830 abstract "Abstract Recombination confers a major evolutionary advantage by breaking up linkage disequilibrium (LD) between harmful and beneficial mutations and facilitating selection. Here, we use genome-wide patterns of LD to infer fine-scale recombination rate variation in the genome of the model green alga Chlamydomonas reinhardtii and estimate rates of LD decay across the entire genome. We observe recombination rate variation of up to two orders of magnitude, finding evidence of recombination hotspots playing a role in the genome. Recombination rate is highest just upstream of genic regions, suggesting the preferential targeting of recombination breakpoints in promoter regions. Furthermore, we observe a positive correlation between GC content and recombination rate, suggesting a role for GC-biased gene conversion or selection on base composition within the GC-rich genome of C. reinhardtii . We also find a positive relationship between nucleotide diversity and recombination, consistent with widespread influence of linked selection in the genome. Finally, we use estimates of the effective rate of recombination to calculate the rate of sex that occurs in natural populations of this important model microbe, estimating a sexual cycle roughly every 770 generations. We argue that the relatively infrequent rate of sex and large effective population size creates an population genetic environment that increases the influence of linked selection on the genome." @default.
- W3100888830 created "2020-11-23" @default.
- W3100888830 creator A5057509913 @default.
- W3100888830 creator A5061447216 @default.
- W3100888830 date "2018-06-07" @default.
- W3100888830 modified "2023-10-16" @default.
- W3100888830 title "The genomic landscape of recombination rate variation in<i>Chlamydomonas reinhardtii</i>reveals a pronounced effect of linked selection" @default.
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- W3100888830 doi "https://doi.org/10.1101/340992" @default.
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